A developmental checkpoint directs metabolic remodelling as a strategy against starvation in Drosophila.
Animals
Behavior, Animal
Body Size
Drosophila
/ metabolism
Drosophila Proteins
/ metabolism
Eating
Ecdysteroids
/ pharmacology
Glycogen
/ metabolism
Insulin-Like Growth Factor Binding Proteins
/ metabolism
Larva
Life History Traits
Lipid Metabolism
Metabolomics
Models, Theoretical
Pupa
/ metabolism
Starvation
/ metabolism
Triglycerides
/ metabolism
Journal
Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
14
04
2020
accepted:
07
09
2020
pubmed:
14
10
2020
medline:
31
12
2020
entrez:
13
10
2020
Statut:
ppublish
Résumé
Steroid hormones are crucial regulators of life-stage transitions during development in animals. However, the molecular mechanisms by which developmental transition through these stages is coupled with optimal metabolic homeostasis remains poorly understood. Here, we demonstrate through mathematical modelling and experimental validation that ecdysteroid-induced metabolic remodelling from resource consumption to conservation can be a successful life-history strategy to maximize fitness in Drosophila larvae in a fluctuating environment. Specifically, the ecdysteroid-inducible protein ImpL2 protects against hydrolysis of circulating trehalose following pupal commitment in larvae. Stored glycogen and triglycerides in the fat body are also conserved, even under fasting conditions. Moreover, pupal commitment dictates reduced energy expenditure upon starvation to maintain available resources, thus negotiating trade-offs in resource allocation at the physiological and behavioural levels. The optimal stage-specific metabolic shift elucidated by our predictive and empirical approaches reveals that Drosophila has developed a highly controlled system for ensuring robust development that may be conserved among higher-order organisms in response to intrinsic and extrinsic cues.
Identifiants
pubmed: 33046910
doi: 10.1038/s42255-020-00293-4
pii: 10.1038/s42255-020-00293-4
doi:
Substances chimiques
Drosophila Proteins
0
Ecdysteroids
0
ImpL2 protein, Drosophila
0
Insulin-Like Growth Factor Binding Proteins
0
Triglycerides
0
Glycogen
9005-79-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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