Stearoyl-CoA desaturase 5 (SCD5), a Δ-9 fatty acyl desaturase in search of a function.
Amino Acid Sequence
Animals
Cell Survival
Cleft Palate
/ enzymology
Fatty Acids
/ metabolism
Fatty Acids, Monounsaturated
/ metabolism
Gene Expression Regulation
Humans
Lipid Metabolism
/ genetics
Neoplasms
/ enzymology
Neurodegenerative Diseases
/ enzymology
Sequence Alignment
Sequence Homology, Amino Acid
Signal Transduction
Stearoyl-CoA Desaturase
/ genetics
Cancer
Desaturase
Developmental diseases
Lipid metabolism
Monounsaturated fatty acids
Signal transduction
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
19
06
2020
revised:
26
09
2020
accepted:
07
10
2020
pubmed:
14
10
2020
medline:
14
4
2021
entrez:
13
10
2020
Statut:
ppublish
Résumé
A large body of research has demonstrated that human stearoyl-CoA desaturase 1 (SCD1), a universally expressed fatty acid Δ9-desaturase that converts saturated fatty acids (SFA) into monounsaturated fatty acids (MUFA), is a central regulator of metabolic and signaling pathways involved in cell proliferation, differentiation, and survival. Unlike SCD1, stearoyl-CoA desaturase 5 (SCD5), a second SCD isoform found in a variety of vertebrates, including humans, has received considerably less attention but new information on the catalytic properties, regulation and biological functions of this enzyme has begun to emerge. This review will examine the new evidence that supports key metabolic and biological roles for SCD5, as well as the potential implication of this desaturase in the mechanisms of human diseases.
Identifiants
pubmed: 33049404
pii: S1388-1981(20)30232-8
doi: 10.1016/j.bbalip.2020.158840
pmc: PMC8533680
mid: NIHMS1636998
pii:
doi:
Substances chimiques
Fatty Acids
0
Fatty Acids, Monounsaturated
0
SCD1 protein, human
EC 1.14.19.1
SCD5 protein, human
EC 1.14.19.1
Stearoyl-CoA Desaturase
EC 1.14.19.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158840Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL144774
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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