The Immune Nature of Platelets Revisited.
Antigen processing and presentation
Bacteria
CD40L
Chemokines
Cytokines
Immune response
Microvesicles
Platelets
TLR
Viruses
Journal
Transfusion medicine reviews
ISSN: 1532-9496
Titre abrégé: Transfus Med Rev
Pays: United States
ID NLM: 8709027
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
13
07
2020
revised:
31
08
2020
accepted:
03
09
2020
pubmed:
15
10
2020
medline:
21
10
2021
entrez:
14
10
2020
Statut:
ppublish
Résumé
Platelets are the primary cellular mediators of hemostasis and this function firmly acquaints them with a variety of inflammatory processes. For example, platelets can act as circulating sentinels by expressing Toll-like receptors (TLR) that bind pathogens and this allows platelets to effectively kill them or present them to cells of the immune system. Furthermore, activated platelets secrete and express many pro- and anti-inflammatory molecules that attract and capture circulating leukocytes and direct them to inflamed tissues. In addition, platelets can directly influence adaptive immune responses via secretion of, for example, CD40 and CD40L molecules. Platelets are also the source of most of the microvesicles in the circulation and these miniscule elements further enhance the platelet's ability to communicate with the immune system. More recently, it has been demonstrated that platelets and their parent cells, the megakaryocytes (MK), can also uptake, process and present both foreign and self-antigens to CD8+ T-cells conferring on them the ability to directly alter adaptive immune responses. This review will highlight several of the non-hemostatic attributes of platelets that clearly and rightfully place them as integral players in immune reactions.
Identifiants
pubmed: 33051111
pii: S0887-7963(20)30050-X
doi: 10.1016/j.tmrv.2020.09.005
pmc: PMC7501063
pii:
doi:
Substances chimiques
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
209-220Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare no competing financial interests.
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