Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence.
Aspergillus fumigatus
TetOFF
antifungal target
doxycycline
established infection
fungal virulence
methionine synthase
primary metabolism
target validation
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
13 10 2020
13 10 2020
Historique:
entrez:
14
10
2020
pubmed:
15
10
2020
medline:
21
7
2021
Statut:
epublish
Résumé
There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH). We show that in
Identifiants
pubmed: 33051366
pii: mBio.01985-20
doi: 10.1128/mBio.01985-20
pmc: PMC7554668
pii:
doi:
Substances chimiques
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
EC 2.1.1.13
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Medical Research Council
ID : G0501164
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L000822/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N008707/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M02010X/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/M017702/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N006364/2
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S001824/1
Pays : United Kingdom
Informations de copyright
Copyright © 2020 Scott et al.
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