LRIG1-Mediated Inhibition of EGF Receptor Signaling Regulates Neural Precursor Cell Proliferation in the Neocortex.
Animals
Animals, Newborn
Cell Proliferation
Cell Self Renewal
Embryo, Mammalian
/ cytology
Embryonic Development
ErbB Receptors
/ metabolism
Membrane Glycoproteins
/ metabolism
Mice
Mice, Knockout
Neocortex
/ cytology
Nerve Tissue Proteins
/ metabolism
Neural Stem Cells
/ cytology
Neurogenesis
Signal Transduction
EGFR
neocortex
neural stem cells
proliferation
quiescence
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
13 10 2020
13 10 2020
Historique:
received:
14
05
2020
revised:
17
08
2020
accepted:
21
09
2020
entrez:
14
10
2020
pubmed:
15
10
2020
medline:
22
9
2021
Statut:
ppublish
Résumé
Here, we ask how neural stem cells (NSCs) transition in the developing neocortex from a rapidly to a slowly proliferating state, a process required to maintain lifelong stem cell pools. We identify LRIG1, known to regulate receptor tyrosine kinase signaling in other cell types, as a negative regulator of cortical NSC proliferation. LRIG1 is expressed in murine cortical NSCs as they start to proliferate more slowly during embryogenesis and then peaks postnatally when they transition to give rise to a portion of adult NSCs. Constitutive or acute loss of Lrig1 in NSCs over this developmental time frame causes stem cell expansion due to increased proliferation. LRIG1 controls NSC proliferation by associating with and negatively regulating the epidermal growth factor receptor (EGFR). These data support a model in which LRIG1 dampens the stem cell response to EGFR ligands within the cortical environment to slow their proliferation as they transition to postnatal adult NSCs.
Identifiants
pubmed: 33053360
pii: S2211-1247(20)31246-8
doi: 10.1016/j.celrep.2020.108257
pii:
doi:
Substances chimiques
Lrig1 protein, mouse
0
Membrane Glycoproteins
0
Nerve Tissue Proteins
0
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
108257Subventions
Organisme : CIHR
Pays : Canada
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.