Prostaglandin E receptors as targets for ischemic stroke: Novel evidence and molecular mechanisms of efficacy.


Journal

Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422

Informations de publication

Date de publication:
01 2021
Historique:
received: 17 07 2020
revised: 28 08 2020
accepted: 05 10 2020
pubmed: 15 10 2020
medline: 18 11 2021
entrez: 14 10 2020
Statut: ppublish

Résumé

Over the past two decades the interest has waned in therapeutically targeting cyclooxygenase-2 (COX-2) due to growing concerns over the potential cardiovascular and cerebrovascular toxicities of the long-term use of COX-2 inhibitors. Attention thus has recently been shifted downstream to the prostaglandin signaling pathways for new druggable anti-inflammatory targets aiming for higher therapeutic specificity. Prostaglandin E2 (PGE

Identifiants

pubmed: 33053444
pii: S1043-6618(20)31546-2
doi: 10.1016/j.phrs.2020.105238
pmc: PMC7854947
mid: NIHMS1637888
pii:
doi:

Substances chimiques

Receptors, Prostaglandin E 0
Cyclooxygenase 2 EC 1.14.99.1
Dinoprostone K7Q1JQR04M

Types de publication

Journal Article Research Support, N.I.H., Extramural Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

105238

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS100947
Pays : United States
Organisme : NINDS NIH HHS
ID : R21 NS109687
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Ltd. All rights reserved.

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Auteurs

Lexiao Li (L)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Madison N Sluter (MN)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Ying Yu (Y)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA.

Jianxiong Jiang (J)

Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN, USA. Electronic address: jjiang18@uthsc.edu.

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Classifications MeSH