Application of Citicoline in Neurological Disorders: A Systematic Review.
Animals
Brain Injuries, Traumatic
/ drug therapy
Cognition
/ drug effects
Cytidine Diphosphate Choline
/ pharmacology
Dementia
/ prevention & control
Disease Models, Animal
Humans
Meta-Analysis as Topic
Nervous System Diseases
/ drug therapy
Neuralgia
/ drug therapy
Neurotransmitter Agents
/ blood
Peripheral Nervous System
/ drug effects
Stroke
/ drug therapy
citicoline
neurology
supplementation
treatment
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
12 Oct 2020
12 Oct 2020
Historique:
received:
05
08
2020
revised:
08
10
2020
accepted:
09
10
2020
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
13
4
2021
Statut:
epublish
Résumé
Citicoline is a chemical compound involved in the synthesis of cell membranes. It also has other, not yet explained functions. Research on the use of citicoline is conducted in neurology, ophthalmology, and psychiatry. Citicoline is widely available as a dietary supplement. It is often used to enhance cognitive functions. In our article, accessible databases were searched for articles regarding citicoline use in neurological diseases. This article has a systemic review form. After rejecting non-eligible reports, 47 remaining articles were reviewed. The review found that citicoline has been proven to be a useful compound in preventing dementia progression. It also enhances cognitive functions among healthy individuals and improves prognosis after stroke. In an animal model of nerve damage and neuropathy, citicoline stimulated regeneration and lessened pain. Among patients who underwent brain trauma, citicoline has an unclear clinical effect. Citicoline has a wide range of effects and could be an essential substance in the treatment of many neurological diseases. Its positive impact on learning and cognitive functions among the healthy population is also worth noting.
Identifiants
pubmed: 33053828
pii: nu12103113
doi: 10.3390/nu12103113
pmc: PMC7601330
pii:
doi:
Substances chimiques
Neurotransmitter Agents
0
Cytidine Diphosphate Choline
536BQ2JVC7
Types de publication
Journal Article
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
Références
Cerebrovasc Dis. 2003;16(3):199-204
pubmed: 12865605
Psychopharmacology (Berl). 2002 May;161(3):248-54
pubmed: 12021827
Neuron. 2010 Jul 29;67(2):181-98
pubmed: 20670828
Methods Find Exp Clin Pharmacol. 2009 Apr;31(3):171-6
pubmed: 19536360
CNS Drugs. 2014 Mar;28(3):185-93
pubmed: 24504829
Methods Find Exp Clin Pharmacol. 2010 Jun;32(5):325-30
pubmed: 20664823
Stroke. 1999 Dec;30(12):2592-7
pubmed: 10582983
J Neurochem. 2013 Sep;126(6):819-26
pubmed: 23600725
Ulus Travma Acil Cerrahi Derg. 2014 Nov;20(6):410-6
pubmed: 25541919
J Neurosci. 2012 Jan 4;32(1):124-32
pubmed: 22219275
J Neurol Neurosurg Psychiatry. 2001 Aug;71(2):225-30
pubmed: 11459898
J Neurosci Res. 2003 Aug 1;73(3):308-15
pubmed: 12868064
J Alzheimers Dis. 2017;56(2):557-565
pubmed: 28035929
Stroke. 2017 Jul;48(7):2007-2012
pubmed: 28626052
Clin Drug Investig. 2016 Dec;36(12):1059-1065
pubmed: 27587069
Neurology. 1997 Sep;49(3):671-8
pubmed: 9305321
Stroke. 1988 Feb;19(2):211-6
pubmed: 3278412
Neurol Res. 2012 Apr;34(3):238-45
pubmed: 22449436
Neurobiol Dis. 2005 Mar;18(2):336-45
pubmed: 15686962
Surg Neurol. 2007 Dec;68(6):615-622
pubmed: 18053855
Clin Interv Aging. 2013;8:131-7
pubmed: 23403474
Rev Neurol. 2016 Dec 23;63(S03):S1-S73
pubmed: 28417449
Methods Find Exp Clin Pharmacol. 1999 Nov;21(9):633-44
pubmed: 10669911
JAMA. 2012 Nov 21;308(19):1993-2000
pubmed: 23168823
Pharmacol Biochem Behav. 2015 Apr;131:119-29
pubmed: 25681529
Rom J Ophthalmol. 2017 Jul-Sep;61(3):152-158
pubmed: 29450391
Wien Klin Wochenschr. 2018 Jan;130(1-2):37-44
pubmed: 28752349
Neurol India. 2015 Sep-Oct;63(5):697-701
pubmed: 26448227
Can J Neurol Sci. 2016 Nov;43(6):774-785
pubmed: 27670907
Neurol Res. 1995 Aug;17(4):281-4
pubmed: 7477743
J BUON. 2013 Oct-Dec;18(4):1012-8
pubmed: 24344031
Nutrients. 2020 Mar 18;12(3):
pubmed: 32197303
Ann Neurol. 2000 Nov;48(5):713-22
pubmed: 11079534
Neurol Res. 2011 Jul;33(6):572-7
pubmed: 21708065
Stat Med. 2019 Sep 20;38(21):4013-4025
pubmed: 31206759
Neurol Res. 2011 Sep;33(7):766-73
pubmed: 21756558
J Stroke Cerebrovasc Dis. 2008 May-Jun;17(3):153-5
pubmed: 18436157
Lancet Neurol. 2011 Mar;10(3):275-9
pubmed: 21349442
Int J Mol Sci. 2016 Mar 16;17(3):390
pubmed: 26999113
Front Endocrinol (Lausanne). 2018 Nov 23;9:702
pubmed: 30532738
J Neurochem. 2002 Jan;80(1):12-23
pubmed: 11796739
Neurology. 2001 Nov 13;57(9):1595-602
pubmed: 11706098
J Neurosci Rural Pract. 2019 Oct;10(4):576-581
pubmed: 31831974
Lancet. 2012 Jul 28;380(9839):349-57
pubmed: 22691567
J Assoc Physicians India. 2012 Nov;60:36-8
pubmed: 23767201
Physiol Behav. 2018 Oct 15;195:151-157
pubmed: 30107190
J Pain Res. 2016 May 23;9:287-91
pubmed: 27284264
Arch Neurol. 1996 May;53(5):441-8
pubmed: 8624220
Clin Neuropharmacol. 2017 Jan/Feb;40(1):1-5
pubmed: 28085707
Int J Food Sci Nutr. 2012 Jun;63(4):421-5
pubmed: 22578105
Neuron. 2014 Feb 5;81(3):471-83
pubmed: 24507186
J Stroke Cerebrovasc Dis. 2016 Aug;25(8):1984-96
pubmed: 27234918
Stroke. 1989 Jul;20(7):864-70
pubmed: 2749846
J Atten Disord. 2019 Jan;23(2):121-134
pubmed: 26179181
Int J Food Sci Nutr. 2014 Dec;65(8):1003-7
pubmed: 25046515
Cerebrovasc Dis. 2006;21(5-6):380-5
pubmed: 16490951
Acta Physiol Pharmacol Bulg. 1990;16(1):25-31
pubmed: 2392950
Nutrients. 2017 Jul 28;9(8):
pubmed: 28788094
Nutrients. 2019 Jul 12;11(7):
pubmed: 31336819
J Surg Res. 2016 Feb;200(2):655-63
pubmed: 26521098
Behav Pharmacol. 2011 Sep;22(5-6):589-98
pubmed: 21836465
Turk Neurosurg. 2014;24(1):54-62
pubmed: 24535792
Cerebrovasc Dis. 2013;35(2):146-54
pubmed: 23406981