Polyamines and Kynurenines at the Intersection of Immune Modulation.
Journal
Trends in immunology
ISSN: 1471-4981
Titre abrégé: Trends Immunol
Pays: England
ID NLM: 100966032
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
18
06
2020
revised:
11
09
2020
accepted:
14
09
2020
pubmed:
16
10
2020
medline:
18
3
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Polyamines (i.e., putrescine, spermidine, and spermine) are bioactive polycations capable of binding nucleic acids and proteins and modulating signaling pathways. Polyamine functions have been studied most extensively in tumors, where they can promote cell transformation and proliferation. Recently, spermidine was found to exert protective effects in an experimental model of multiple sclerosis (MS) and to confer immunoregulatory properties on dendritic cells (DCs), via the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme. IDO1 converts l-tryptophan into metabolites, collectively known as kynurenines, endowed with several immunoregulatory effects via activation of the arylhydrocarbon receptor (AhR). Because AhR activation increases polyamine production, the emerging scenario has identified polyamines and kynurenines as actors of an immunoregulatory circuitry with potential implications for immunotherapy in autoimmune diseases and cancer.
Identifiants
pubmed: 33055013
pii: S1471-4906(20)30214-3
doi: 10.1016/j.it.2020.09.007
pii:
doi:
Substances chimiques
Polyamines
0
Kynurenine
343-65-7
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1037-1050Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.