Horizontal gene transfer potentiates adaptation by reducing selective constraints on the spread of genetic variation.
antibiotic resistance
experimental evolution
horizontal gene transfer
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
27 10 2020
27 10 2020
Historique:
pubmed:
16
10
2020
medline:
18
12
2020
entrez:
15
10
2020
Statut:
ppublish
Résumé
Horizontal gene transfer (HGT) confers the rapid acquisition of novel traits and is pervasive throughout microbial evolution. Despite the central role of HGT, the evolutionary forces that drive the dynamics of HGT alleles in evolving populations are poorly understood. Here, we show that HGT alters the evolutionary dynamics of genetic variation, so that deleterious genetic variants, including antibiotic resistance genes, can establish in populations without selection. We evolve antibiotic-sensitive populations of the human pathogen
Identifiants
pubmed: 33055207
pii: 2005331117
doi: 10.1073/pnas.2005331117
pmc: PMC7604491
doi:
Substances chimiques
Anti-Bacterial Agents
0
Metronidazole
140QMO216E
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
26868-26875Déclaration de conflit d'intérêts
The authors declare no competing interest.
Références
Nat Rev Genet. 2015 Aug;16(8):472-82
pubmed: 26184597
Nat Ecol Evol. 2019 Apr;3(4):515-517
pubmed: 30886376
Genome Biol Evol. 2014 Jun 10;6(7):1589-602
pubmed: 24916661
Nat Rev Gastroenterol Hepatol. 2017 Jul;14(7):383-384
pubmed: 28465548
PLoS Biol. 2019 Jan 23;17(1):e3000102
pubmed: 30673701
PLoS Pathog. 2010 Jul 29;6(7):e1001026
pubmed: 20686662
Trends Ecol Evol. 2013 Nov;28(11):659-69
pubmed: 24075201
Nat Commun. 2017 Nov 22;8(1):1689
pubmed: 29162798
Nature. 2016 Mar 10;531(7593):233-6
pubmed: 26909573
J Comput Biol. 2012 May;19(5):455-77
pubmed: 22506599
Nat Biotechnol. 2011 Jan;29(1):24-6
pubmed: 21221095
Proc Natl Acad Sci U S A. 2020 Oct 27;117(43):26868-26875
pubmed: 33055207
Nucleic Acids Res. 2010 Oct;38(18):6089-101
pubmed: 20478826
Brief Bioinform. 2013 Mar;14(2):178-92
pubmed: 22517427
Nat Commun. 2016 Jun 22;7:11995
pubmed: 27329939
EMBO Rep. 2019 Aug;20(8):e46992
pubmed: 31338963
Mol Biol Evol. 2005 Aug;22(8):1721-32
pubmed: 15901840
Nature. 2013 Aug 29;500(7464):571-4
pubmed: 23873039
Nature. 2019 Sep;573(7773):276-280
pubmed: 31485077
Mol Biol Evol. 2014 Dec;31(12):3228-39
pubmed: 25172959
ISME J. 2017 Aug;11(8):1930-1932
pubmed: 28362724
Mol Biol Evol. 2014 May;31(5):1220-7
pubmed: 24536043
J Bacteriol. 2000 Sep;182(18):5082-90
pubmed: 10960091
PLoS Genet. 2014 Mar 06;10(3):e1004182
pubmed: 24603313
Trends Ecol Evol. 2013 Aug;28(8):489-95
pubmed: 23706556
Science. 2007 Nov 30;318(5855):1449-52
pubmed: 17947550
J Bacteriol. 2000 Sep;182(18):5091-6
pubmed: 10960092
Nat Commun. 2017 Dec 13;8(1):2112
pubmed: 29235478
Mol Biol Evol. 2018 Jan 1;35(1):180-201
pubmed: 29069452
Mol Microbiol. 1998 Apr;28(2):383-93
pubmed: 9622362
Clin Infect Dis. 1997 Jan;24 Suppl 1:S9-16
pubmed: 8994776
PLoS Genet. 2018 Jan 31;14(1):e1007199
pubmed: 29385126
Environ Int. 2019 Apr;125:90-96
pubmed: 30711653
ISME J. 2016 Jul;10(7):1589-601
pubmed: 26744812
Mol Biol Evol. 2002 Dec;19(12):2265-76
pubmed: 12446817
Nature. 2017 Nov 2;551(7678):45-50
pubmed: 29045390
Sci Rep. 2017 Nov 23;7(1):16140
pubmed: 29170397
BMC Evol Biol. 2018 Apr 19;18(1):54
pubmed: 29673327
FEMS Microbiol Rev. 2013 May;37(3):336-63
pubmed: 22928673
Methods Mol Biol. 2014;1151:165-88
pubmed: 24838886
Nature. 2013 Jan 3;493(7430):45-50
pubmed: 23222524