Remdesivir against COVID-19 and Other Viral Diseases.
Adenosine Monophosphate
/ analogs & derivatives
Alanine
/ analogs & derivatives
Antiviral Agents
/ pharmacokinetics
Betacoronavirus
/ drug effects
COVID-19
Clinical Trials as Topic
Compassionate Use Trials
/ methods
Coronavirus Infections
/ drug therapy
Drug Administration Schedule
Ebolavirus
/ drug effects
Hemorrhagic Fever, Ebola
/ drug therapy
Humans
Middle East Respiratory Syndrome Coronavirus
/ drug effects
Pandemics
Patient Safety
Pneumonia, Viral
/ drug therapy
Severe acute respiratory syndrome-related coronavirus
/ drug effects
SARS-CoV-2
Severe Acute Respiratory Syndrome
/ drug therapy
Survival Analysis
Treatment Outcome
COVID-19
MERS-CoV
SARS-CoV
SARS-CoV-2
antiviral
coronavirus
ebolavirus
remdesivir
Journal
Clinical microbiology reviews
ISSN: 1098-6618
Titre abrégé: Clin Microbiol Rev
Pays: United States
ID NLM: 8807282
Informations de publication
Date de publication:
16 12 2020
16 12 2020
Historique:
entrez:
15
10
2020
pubmed:
16
10
2020
medline:
30
10
2020
Statut:
epublish
Résumé
Patients and physicians worldwide are facing tremendous health care hazards that are caused by the ongoing severe acute respiratory distress syndrome coronavirus 2 (SARS-CoV-2) pandemic. Remdesivir (GS-5734) is the first approved treatment for severe coronavirus disease 2019 (COVID-19). It is a novel nucleoside analog with a broad antiviral activity spectrum among RNA viruses, including ebolavirus (EBOV) and the respiratory pathogens Middle East respiratory syndrome coronavirus (MERS-CoV), SARS-CoV, and SARS-CoV-2. First described in 2016, the drug was derived from an antiviral library of small molecules intended to target emerging pathogenic RNA viruses.
Identifiants
pubmed: 33055231
pii: 34/1/e00162-20
doi: 10.1128/CMR.00162-20
pmc: PMC7566896
pii:
doi:
Substances chimiques
Antiviral Agents
0
remdesivir
3QKI37EEHE
Adenosine Monophosphate
415SHH325A
Alanine
OF5P57N2ZX
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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