Persistent Interferon Production by Double Negative T Cells and Collapsing Focal Segmental Glomerulosclerosis.
Autoimmune lymphoproliferative disorder
Collapsing glomerulopathy
Double negative T cell
Focal segmental glomerulosclerosis
Interferon gamma
Journal
Nephron
ISSN: 2235-3186
Titre abrégé: Nephron
Pays: Switzerland
ID NLM: 0331777
Informations de publication
Date de publication:
2021
2021
Historique:
received:
14
07
2020
accepted:
08
08
2020
pubmed:
16
10
2020
medline:
9
11
2021
entrez:
15
10
2020
Statut:
ppublish
Résumé
Collapsing glomerulopathy has multiple associations, including viral infections, medications like bisphosphonates and interferon, autoimmune diseases, and genetic predisposition. We report a case of collapsing focal segmental glomerulosclerosis associated with persistently high levels of interferon gamma produced by T-cell receptor αβ (+), CD4- CD8- (double negative) T lymphocytes that progressed despite treatment and improvement of other cytokine levels. Double negative T cells are elevated and activated in autoimmune lymphoproliferative syndrome (ALPS). Production of elevated interferon gamma levels from double negative T cells in ALPS despite treatment provides insight to the pathophysiology of collapsing glomerulopathy, guiding future research for collapsing glomerulopathy.
Identifiants
pubmed: 33059348
pii: 000510759
doi: 10.1159/000510759
pmc: PMC7785627
mid: NIHMS1625114
doi:
Substances chimiques
Interferons
9008-11-1
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
85-90Subventions
Organisme : NIDDK NIH HHS
ID : P01 DK056492
Pays : United States
Informations de copyright
© 2020 S. Karger AG, Basel.
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