Sphingomyelin synthase 2 loss suppresses steatosis but exacerbates fibrosis in the liver of mice fed with choline-deficient, L-amino acid-defined, high-fat diet.
Amino Acids
/ administration & dosage
Animals
Chemical and Drug Induced Liver Injury
/ etiology
Choline
/ physiology
Diet, High-Fat
Fatty Liver
/ etiology
Liver
/ metabolism
Liver Cirrhosis
/ etiology
Lysophospholipids
/ metabolism
Mice, Knockout
Signal Transduction
Sphingosine
/ analogs & derivatives
Transferases (Other Substituted Phosphate Groups)
/ genetics
Lipotoxicity
Liver fibrosis
Sphingolipids
Sphingomyelin synthase 2
Sphingosine 1-phosphae
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
17 12 2020
17 12 2020
Historique:
received:
27
09
2020
accepted:
30
09
2020
pubmed:
17
10
2020
medline:
18
3
2021
entrez:
16
10
2020
Statut:
ppublish
Résumé
Sphingomyelin synthase 2 (SMS2) regulates sphingomyelin synthesis and contributes to obesity and hepatic steatosis. Here, we investigated the effect of SMS2 deficiency on liver fibrosis in mice fed with choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) or injected with carbon tetrachloride (CCl
Identifiants
pubmed: 33059919
pii: S0006-291X(20)31902-1
doi: 10.1016/j.bbrc.2020.09.142
pii:
doi:
Substances chimiques
Amino Acids
0
Lysophospholipids
0
sphingosine 1-phosphate
26993-30-6
Transferases (Other Substituted Phosphate Groups)
EC 2.7.8.-
Sgms2 protein, mouse
EC 2.7.8.27
Choline
N91BDP6H0X
Sphingosine
NGZ37HRE42
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1269-1275Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors, M.S., T.H., M.W., T.Y., H.K., R.N., H.K., Y.N. and H.Y. are employees of Shionogi & Co., Ltd. M.S. is an employee of Shionogi TechnoAdvance Research Co., Ltd. Y.I. got advisory fees from Shionogi & Co., Ltd.