[Isolated plasmablastic lymphoma of nasal mucosa in an immunocompetent patient achieving complete remission after multimodal treatment: about an African patient and literature review].
Lymphome plasmablastique de la muqueuse nasale isolée chez un patient immunocompétent en rémission complète après traitement multimodale: à propos d’un cas Africain et revue de la littérature.
Antineoplastic Combined Chemotherapy Protocols
/ administration & dosage
Biopsy
Cyclophosphamide
/ administration & dosage
Doxorubicin
/ administration & dosage
Etoposide
/ administration & dosage
Humans
Male
Middle Aged
Nasal Mucosa
/ pathology
Neoplasm Staging
Nose Neoplasms
/ pathology
Plasmablastic Lymphoma
/ pathology
Prednisolone
/ administration & dosage
Remission Induction
Tomography, X-Ray Computed
Vincristine
/ administration & dosage
HIV
Plasmablastic lymphoma
nasal
radiotherapy
Journal
The Pan African medical journal
ISSN: 1937-8688
Titre abrégé: Pan Afr Med J
Pays: Uganda
ID NLM: 101517926
Informations de publication
Date de publication:
2020
2020
Historique:
received:
19
12
2019
accepted:
13
07
2020
entrez:
16
10
2020
pubmed:
17
10
2020
medline:
8
1
2021
Statut:
epublish
Résumé
Plasmablastic lymphoma is an aggressive variant of lymphomas recently distinct from diffuse large B cell lymphoma. It has been initially described as a disease affecting the oral cavity of immunocompromised patients. We here report the first case of a 54-year-old patient with nasal septum nodule, bleeding on contact and after sneezing which occurred 6 months before admission. Facial computed tomography (CT) scan showed thickening of the nasal mucosa of 14mm. Excisional biopsy showed tumor proliferation composed of plasmablastic cells with immunophenotypic features: CD 138+, ki67 80%, EMA+, CD79a+, CD 56+. Staging and HIV serology were negative. Given the rarity of this lymphoma there are no standard treatments and most patients have treatment-resistant lymphoma with poor prognosis. Our patient received 6 cycles of CHOP-like chemotherapy associated with 40 gy radiotherapy in 20 fractions of 2 gy with complete remission (unusual in the cases described in the literature).
Identifiants
pubmed: 33062124
doi: 10.11604/pamj.2020.37.22.21352
pii: PAMJ-37-22
pmc: PMC7532850
doi:
Substances chimiques
Vincristine
5J49Q6B70F
Etoposide
6PLQ3CP4P3
Doxorubicin
80168379AG
Cyclophosphamide
8N3DW7272P
Prednisolone
9PHQ9Y1OLM
Types de publication
Case Reports
Journal Article
Review
Langues
fre
Sous-ensembles de citation
IM
Pagination
22Informations de copyright
Copyright: Rajaa Tissir et al.
Déclaration de conflit d'intérêts
Les auteurs ne déclarent aucun conflit d’intérêts.
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