Recurrent co-alteration of HDGF and SETDB1 on chromosome 1q drives cutaneous melanoma progression and poor prognosis.
Animals
Biomarkers, Tumor
/ genetics
Chromosomes, Human, Pair 1
/ genetics
Follow-Up Studies
Gene Expression Regulation, Neoplastic
Histone-Lysine N-Methyltransferase
/ genetics
Humans
Intercellular Signaling Peptides and Proteins
/ genetics
Melanoma
/ genetics
Mutation
Prognosis
Proto-Oncogene Proteins B-raf
/ genetics
Skin Neoplasms
/ genetics
Survival Rate
Zebrafish
Journal
Pigment cell & melanoma research
ISSN: 1755-148X
Titre abrégé: Pigment Cell Melanoma Res
Pays: England
ID NLM: 101318927
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
08
10
2020
received:
01
06
2020
accepted:
12
10
2020
pubmed:
17
10
2020
medline:
11
1
2022
entrez:
16
10
2020
Statut:
ppublish
Résumé
A progressive increase in copy number variation (CNV) characterizes the natural history of cutaneous melanoma progression toward later disease stages, but our understanding of genetic drivers underlying chromosomal arm-level CNVs remains limited. To identify candidate progression drivers, we mined the TCGA SKCM dataset and identified HDGF as a recurrently amplified gene whose high mRNA expression correlates with poor patient survival. Using melanocyte-specific overexpression in the zebrafish BRAF
Identifiants
pubmed: 33064882
doi: 10.1111/pcmr.12937
pmc: PMC8050117
mid: NIHMS1683752
doi:
Substances chimiques
Biomarkers, Tumor
0
Intercellular Signaling Peptides and Proteins
0
hepatoma-derived growth factor
0
Histone-Lysine N-Methyltransferase
EC 2.1.1.43
SETDB1 protein, human
EC 2.1.1.43
BRAF protein, human
EC 2.7.11.1
Proto-Oncogene Proteins B-raf
EC 2.7.11.1
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
641-647Subventions
Organisme : NCI NIH HHS
ID : P01 CA163222
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA103846
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007627
Pays : United States
Informations de copyright
© 2020 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.
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