Hypercoagulability in Vestibular Schwannoma Surgery.


Journal

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
ISSN: 1537-4505
Titre abrégé: Otol Neurotol
Pays: United States
ID NLM: 100961504

Informations de publication

Date de publication:
01 02 2021
Historique:
pubmed: 17 10 2020
medline: 22 4 2021
entrez: 16 10 2020
Statut: ppublish

Résumé

Patients with vestibular schwannoma who harbor a genetic predisposition for venous thromboembolism require special consideration when determining optimal therapeutic management. The primary objective of the current study was to provide recommendations on treatment of hypercoagulable patients with vestibular schwannoma through a case series and review of the literature. Two patients who underwent resection of vestibular schwannomas. Surgical resection and diagnostic testing. Postoperative venous thromboses. One patient who underwent resection of vestibular schwannoma and suffered several postoperative thrombotic complications consistent with a clinical thrombophilia. One patient with known Factor V Leiden deficiency who underwent resection of vestibular schwannoma followed by postoperative chemoprophylaxis with a direct factor Xa inhibitor and experienced an uneventful postoperative course. In patients with a known propensity for venous thromboembolism, the skull base surgeon should consider nonsurgical management. If the patient undergoes surgical resection, we recommend careful effort to minimize trauma to the sigmoid sinus. In addition, the surgeon may consider retrosigmoid or middle fossa approaches. Best practice recommendations include the use of pneumatic compression devices, early ambulation, and consideration of postoperative prophylactic anticoagulation in patients with a known genetic predisposition.

Identifiants

pubmed: 33065597
pii: 00129492-202102000-00036
doi: 10.1097/MAO.0000000000002934
doi:

Types de publication

Case Reports Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

e222-e226

Informations de copyright

Copyright © 2020, Otology & Neurotology, Inc.

Déclaration de conflit d'intérêts

The authors disclose no conflicts of interest.

Références

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Auteurs

Thomas J Muelleman (TJ)

Division of Neurotology, House Ear Institute.
Department of Head and Neck Surgery, UCLA Medical Center.

Jose Alonso (J)

Department of Head and Neck Surgery, UCLA Medical Center.

Zachary R Barnard (ZR)

Department of Neurosurgery, Cedars Sinai Hospital.

Anne K Maxwell (AK)

Division of Neurotology, House Ear Institute.
Department of Head and Neck Surgery, UCLA Medical Center.

Hossein Mahboubi (H)

Division of Neurotology, House Ear Institute.
Department of Head and Neck Surgery, UCLA Medical Center.

Michael Stefan (M)

Division of Neurotology, House Ear Institute.

Gregory P Lekovic (GP)

Division of Neurosurgery, House Ear Institute, Los Angeles, California.

William H Slattery (WH)

Division of Neurotology, House Ear Institute.

Derald E Brackmann (DE)

Division of Neurotology, House Ear Institute.

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