Spontaneous Epidural Hematomas due to Cerebral Venous Thrombosis in a Patient with Immune Thrombocytopenic Purpura.
Adult
Anticoagulants
/ adverse effects
Cerebral Hemorrhage
/ diagnostic imaging
Fatal Outcome
Female
Hematoma, Epidural, Cranial
/ diagnostic imaging
Humans
Intracranial Thrombosis
/ diagnostic imaging
Purpura, Thrombocytopenic, Idiopathic
/ complications
Risk Factors
Treatment Outcome
Venous Thrombosis
/ diagnostic imaging
Cerebral venous thrombosis
Epidural hematoma
Immune thrombocytopenic purpura
Intracranial hemorrhage
Journal
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
ISSN: 1532-8511
Titre abrégé: J Stroke Cerebrovasc Dis
Pays: United States
ID NLM: 9111633
Informations de publication
Date de publication:
Nov 2020
Nov 2020
Historique:
received:
22
05
2020
revised:
06
08
2020
accepted:
08
08
2020
entrez:
17
10
2020
pubmed:
18
10
2020
medline:
15
12
2020
Statut:
ppublish
Résumé
Intracerebral haemorrhage in patients suffering from cerebral venous thrombosis (CVT) is relatively uncommon. CVT typically occurs in hypercoagulable state of various causes. Some drugs play a causative role in CVT and thrombopoietin receptor agonists are among them. We present a female patient with refractory immune thrombocytopenic purpura (ITP) treated with romiplostim, suffering from severe thrombosis of jugular vein expanding intracranially. Despite being treated with adequate anticoagulation, she developed spontaneous bilateral epidural and subdural hematomas with devastating outcome. To our knowledge, this is the first reported case of spontaneous atraumatic epidural hematomas due to CVT in adult patient. We support that in our patient, blood stasis leading to the dissection of dura mater, platelet dysfunction, and anticoagulation treatment contributed to the formation of the intracranial, extracerebral haemorrhages.
Identifiants
pubmed: 33066947
pii: S1052-3057(20)30662-5
doi: 10.1016/j.jstrokecerebrovasdis.2020.105244
pii:
doi:
Substances chimiques
Anticoagulants
0
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
105244Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.