Efficacy and safety profile of deep responders to carfilzomib-based therapy: a subgroup analysis from ASPIRE and ENDEAVOR.


Journal

Leukemia
ISSN: 1476-5551
Titre abrégé: Leukemia
Pays: England
ID NLM: 8704895

Informations de publication

Date de publication:
06 2021
Historique:
received: 05 05 2020
accepted: 29 09 2020
revised: 30 07 2020
pubmed: 18 10 2020
medline: 17 8 2021
entrez: 17 10 2020
Statut: ppublish

Résumé

To understand the profile of best responders (complete response or better [≥CR]) to carfilzomib, we described the characteristics, progression-free survival (PFS), overall survival (OS) data, and the safety of patients who achieved ≥CR to carfilzomib-based treatment in ASPIRE and ENDEAVOR. In post hoc analyses from ASPIRE and ENDEAVOR, median PFS and OS were longer for ≥CR patients versus those who achieved a very good partial response or partial response (VGPR/PR). In the carfilzomib arm of ASPIRE, median PFS was 50.4 months for ≥CR versus 22.1 months for VGPR/PR; median OS was 67.0 versus 44.2 months, respectively. In the carfilzomib arm of ENDEAVOR, median PFS was 34.0 for ≥CR versus 20.4 months for VGPR/PR; median OS was non-estimable. Despite the longer treatment duration, fewer patients with ≥CR versus VGPR/PR experienced treatment-emergent adverse events that led to discontinuation of carfilzomib-based treatment in ASPIRE or ENDEAVOR. Low serum lactate dehydrogenase was the only factor associated with achieving ≥CR vs patients not achieving CR in ASPIRE in multivariate regression analyses. No association was found between cytogenetic risk status and reaching ≥CR. Carfilzomib treatment may lead to rapid and deep responses, irrespective of most patient characteristics.

Identifiants

pubmed: 33067574
doi: 10.1038/s41375-020-01049-5
pii: 10.1038/s41375-020-01049-5
pmc: PMC8179852
doi:

Substances chimiques

Oligopeptides 0
carfilzomib 72X6E3J5AR
Dexamethasone 7S5I7G3JQL
Lenalidomide F0P408N6V4

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1732-1744

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Auteurs

Katja Weisel (K)

Department of Oncology and Hematology, University Medical Center of Hamburg-Eppendorf, Hamburg, Germany. k.weisel@uke.de.

Maria-Victoria Mateos (MV)

Institute of Biomedical Research of Salamanca (IBSAL), Cancer Research Center-IBMCC (USAL-CSIC), and Hematology Department, University Hospital of Salamanca, Salamanca, Spain.

Francesca Gay (F)

Myeloma Unit, Division of Hematology, Azienda Ospedaliero Universitaria Città della Salute e della Scienza, University of Turin, Turin, Italy.

Michel Delforge (M)

Department of Hematology, University Hospital (UZ) Leuven, Leuven, Belgium.

Gordon Cook (G)

Department of Haematology, Leeds Cancer Centre, St James's University Hospital, Leeds, UK.

Zsolt Szabo (Z)

Amgen (Europe) GmbH, Rotkreuz, Switzerland.

Renaud Desgraz (R)

Amgen (Europe) GmbH, Rotkreuz, Switzerland.

Lucy DeCosta (L)

Global Biostatistical Science, Amgen Ltd, Cambridge, UK.

Philippe Moreau (P)

Hematology Department, University Hospital Hôtel-Dieu, Nantes, France.

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