Genomic and drug target evaluation of 90 cardiovascular proteins in 30,931 individuals.

ATP Binding Cassette Transporter 1 / genetics Asthma / genetics Cardiovascular System / metabolism Chromosome Mapping Drug Delivery Systems Gene Knockdown Techniques Genome-Wide Association Study Genomics Humans Inflammatory Bowel Diseases / genetics Interleukin-1 Receptor-Like 1 Protein / genetics Intracellular Signaling Peptides and Proteins / genetics Linkage Disequilibrium Mendelian Randomization Analysis Protein Serine-Threonine Kinases / antagonists & inhibitors Proteome Quantitative Trait Loci Receptors, CCR2 / genetics Receptors, CCR5 / genetics

Journal

Nature metabolism
ISSN: 2522-5812
Titre abrégé: Nat Metab
Pays: Germany
ID NLM: 101736592

Informations de publication

Date de publication:
10 2020
Historique:
received: 14 01 2020
accepted: 02 09 2020
entrez: 17 10 2020
pubmed: 18 10 2020
medline: 31 12 2020
Statut: ppublish

Résumé

Circulating proteins are vital in human health and disease and are frequently used as biomarkers for clinical decision-making or as targets for pharmacological intervention. Here, we map and replicate protein quantitative trait loci (pQTL) for 90 cardiovascular proteins in over 30,000 individuals, resulting in 451 pQTLs for 85 proteins. For each protein, we further perform pathway mapping to obtain trans-pQTL gene and regulatory designations. We substantiate these regulatory findings with orthogonal evidence for trans-pQTLs using mouse knockdown experiments (ABCA1 and TRIB1) and clinical trial results (chemokine receptors CCR2 and CCR5), with consistent regulation. Finally, we evaluate known drug targets, and suggest new target candidates or repositioning opportunities using Mendelian randomization. This identifies 11 proteins with causal evidence of involvement in human disease that have not previously been targeted, including EGF, IL-16, PAPPA, SPON1, F3, ADM, CASP-8, CHI3L1, CXCL16, GDF15 and MMP-12. Taken together, these findings demonstrate the utility of large-scale mapping of the genetics of the proteome and provide a resource for future precision studies of circulating proteins in human health.

Identifiants

DOI: 10.1038/s42255-020-00287-2 PMID: 33067605 PMC: PMC7611474
pubmed: 33067605
doi: 10.1038/s42255-020-00287-2
pii: 10.1038/s42255-020-00287-2
pmc: PMC7611474
mid: EMS131454
doi:

Substances chimiques

ABCA1 protein, mouse 0
ATP Binding Cassette Transporter 1 0
CCR2 protein, human 0
CCR5 protein, human 0
IL1RL1 protein, human 0
Interleukin-1 Receptor-Like 1 Protein 0
Intracellular Signaling Peptides and Proteins 0
Proteome 0
Receptors, CCR2 0
Receptors, CCR5 0
Trib1 protein, mouse 0
Protein Serine-Threonine Kinases EC 2.7.11.1

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1135-1148

Subventions

Organisme : Medical Research Council
ID : MR/L003120/1
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZB/4/710
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S004068/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00011/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S004068/2
Pays : United Kingdom
Organisme : European Research Council
ID : 637640
Pays : International
Organisme : European Research Council
ID : 335395
Pays : International
Organisme : Arthritis Research UK
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_U127592696
Pays : United Kingdom
Organisme : Chief Scientist Office
ID : CZB/4/276
Pays : United Kingdom
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 204979/Z/16/Z
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/13/13/30194
Pays : United Kingdom
Organisme : British Heart Foundation
ID : SP/09/002
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/S003746/1
Pays : United Kingdom
Organisme : NHLBI NIH HHS
ID : R01 HL139731
Pays : United States
Organisme : Department of Health
ID : BTRU-2014-10024
Pays : United Kingdom
Organisme : British Heart Foundation
ID : FS/18/23/33512
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RG/18/13/33946
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom

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Auteurs

Lasse Folkersen (L)

Department of Medicine, Karolinska Institute, Solna, Sweden.
Danish National Genome Center, Copenhagen, Denmark.
SCALLOP consortium.
ORCID: 0000-0003-0708-9530

Stefan Gustafsson (S)

SCALLOP consortium.
Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.

Qin Wang (Q)

SCALLOP consortium.
Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.

Daniel Hvidberg Hansen (DH)

SCALLOP consortium.
Intomics A/S, Kgs. Lyngby, Denmark.
ORCID: 0000-0003-3285-605X

Åsa K Hedman (ÅK)

Department of Medicine, Karolinska Institute, Solna, Sweden.
SCALLOP consortium.
Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.

Andrew Schork (A)

SCALLOP consortium.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region, Roskilde, Denmark.
Neurogenomics Division, The Translational Genomics Research Institute (TGEN), Phoenix, AZ, USA.

Karen Page (K)

SCALLOP consortium.
Early Clinical Development, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.

Daria V Zhernakova (DV)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Yang Wu (Y)

SCALLOP consortium.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
ORCID: 0000-0002-0128-7280

James Peters (J)

SCALLOP consortium.
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
Department of Immunology and Inflammation, Faculty of Medicine, Imperial College London, London, UK.

Niclas Eriksson (N)

SCALLOP consortium.
Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-2152-4343

Sarah E Bergen (SE)

SCALLOP consortium.
Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.

Thibaud S Boutin (TS)

SCALLOP consortium.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.

Andrew D Bretherick (AD)

SCALLOP consortium.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
ORCID: 0000-0001-9258-3140

Stefan Enroth (S)

SCALLOP consortium.
Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-5056-9137

Anette Kalnapenkis (A)

SCALLOP consortium.
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.

Jesper R Gådin (JR)

Department of Medicine, Karolinska Institute, Solna, Sweden.
SCALLOP consortium.

Bianca E Suur (BE)

SCALLOP consortium.
Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden.

Yan Chen (Y)

Department of Medicine, Karolinska Institute, Solna, Sweden.
SCALLOP consortium.

Ljubica Matic (L)

SCALLOP consortium.
Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Sweden.

Jeremy D Gale (JD)

SCALLOP consortium.
Inflammation and Immunology Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.

Julie Lee (J)

SCALLOP consortium.
Early Clinical Development, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.
ORCID: 0000-0001-6090-6718

Weidong Zhang (W)

SCALLOP consortium.
Pfizer Global Product Development, Cambridge, MA, USA.

Amira Quazi (A)

SCALLOP consortium.
Early Clinical Development, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.

Mika Ala-Korpela (M)

SCALLOP consortium.
Systems Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Computational Medicine, Faculty of Medicine, University of Oulu and Biocenter Oulu, Oulu, Finland.
NMR Metabolomics Laboratory, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
ORCID: 0000-0001-5905-1206

Seung Hoan Choi (SH)

SCALLOP consortium.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.

Annique Claringbould (A)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-9201-6557

John Danesh (J)

SCALLOP consortium.
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
Department of Human Genetics, Wellcome Sanger Institute, Hinxton, UK.

George Davey Smith (G)

SCALLOP consortium.
MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
ORCID: 0000-0002-1407-8314

Federico de Masi (F)

SCALLOP consortium.
Intomics A/S, Kgs. Lyngby, Denmark.

Sölve Elmståhl (S)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

Gunnar Engström (G)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

Eric Fauman (E)

SCALLOP consortium.
Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.
ORCID: 0000-0002-9739-0249

Celine Fernandez (C)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
ORCID: 0000-0003-1290-4982

Lude Franke (L)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0002-5159-8802

Paul W Franks (PW)

SCALLOP consortium.
Department of Clinical Sciences, Lund University Diabetes Center, Malmö, Sweden.
ORCID: 0000-0002-0520-7604

Vilmantas Giedraitis (V)

SCALLOP consortium.
Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-3423-2021

Chris Haley (C)

SCALLOP consortium.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
ORCID: 0000-0002-9811-0210

Anders Hamsten (A)

Department of Medicine, Karolinska Institute, Solna, Sweden.
SCALLOP consortium.

Andres Ingason (A)

SCALLOP consortium.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region, Roskilde, Denmark.

Åsa Johansson (Å)

SCALLOP consortium.
Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala University, Uppsala, Sweden.
ORCID: 0000-0002-2915-4498

Peter K Joshi (PK)

SCALLOP consortium.
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Lars Lind (L)

SCALLOP consortium.
Department of Medical Sciences, Uppsala University, Uppsala, Sweden.

Cecilia M Lindgren (CM)

SCALLOP consortium.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Big Data Institute at the Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.

Steven Lubitz (S)

SCALLOP consortium.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA.
ORCID: 0000-0002-9599-4866

Tom Palmer (T)

SCALLOP consortium.
Department of Mathematics and Statistics, University of Lancaster, Lancaster, UK.
ORCID: 0000-0003-4655-4511

Erin Macdonald-Dunlop (E)

SCALLOP consortium.
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.
ORCID: 0000-0001-6569-6086

Martin Magnusson (M)

SCALLOP consortium.
Department of Cardiology, Skåne University Hospital Malmö, Malmö, Sweden.
Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
North-West University, Hypertension in Africa Research Team (HART), Potchefstroom, South Africa.
ORCID: 0000-0003-1710-5936

Olle Melander (O)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

Karl Michaelsson (K)

SCALLOP consortium.
Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
ORCID: 0000-0003-2815-1217

Andrew P Morris (AP)

SCALLOP consortium.
Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester, UK.
Department of Biostatistics, University of Liverpool, Liverpool, UK.

Reedik Mägi (R)

SCALLOP consortium.
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Michael W Nagle (MW)

SCALLOP consortium.
Internal Medicine Research Unit, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA.
ORCID: 0000-0002-4677-7582

Peter M Nilsson (PM)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
ORCID: 0000-0002-5652-8459

Jan Nilsson (J)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.
ORCID: 0000-0002-9752-7479

Marju Orho-Melander (M)

SCALLOP consortium.
Department of Clinical Sciences, Clinical Research Center, Lund University, Malmö, Sweden.

Ozren Polasek (O)

SCALLOP consortium.
Faculty of Medicine, University of Split, Split, Croatia.

Bram Prins (B)

SCALLOP consortium.
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-5774-034X

Erik Pålsson (E)

SCALLOP consortium.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Ting Qi (T)

SCALLOP consortium.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.

Marketa Sjögren (M)

SCALLOP consortium.
Department of Clinical Sciences, Lund University, Skåne University Hospital, Malmö, Sweden.

Johan Sundström (J)

SCALLOP consortium.
Department of Medical Sciences, Clinical Epidemiology, Uppsala University, Uppsala, Sweden.
The George Institute for Global Health, University of New South Wales, Sydney, New South Wales, Australia.
ORCID: 0000-0003-2247-8454

Praveen Surendran (P)

SCALLOP consortium.
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.

Urmo Võsa (U)

SCALLOP consortium.
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.

Thomas Werge (T)

SCALLOP consortium.
Institute of Biological Psychiatry, Mental Health Center Sct. Hans, Mental Health Services Capital Region, Roskilde, Denmark.
ORCID: 0000-0003-1829-0766

Rasmus Wernersson (R)

SCALLOP consortium.
Intomics A/S, Kgs. Lyngby, Denmark.

Harm-Jan Westra (HJ)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-7038-567X

Jian Yang (J)

SCALLOP consortium.
Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia.
Institute for Advanced Research, Wenzhou Medical University, Wenzhou, China.
School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China.

Alexandra Zhernakova (A)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.

Johan Ärnlöv (J)

SCALLOP consortium.
Department of Neurobiology, Care Sciences and Society (NVS) Division of Family Medicine and Primary Care, Karolinska Institute, Solna, Sweden.

Jingyuan Fu (J)

SCALLOP consortium.
Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Department of Paediatrics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
ORCID: 0000-0001-5578-1236

J Gustav Smith (JG)

SCALLOP consortium.
Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden.
Department of Cardiology, Clinical Sciences, Lund University and Skåne University Hospital, Lund, Sweden.

Tõnu Esko (T)

SCALLOP consortium.
Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA.
ORCID: 0000-0003-1982-6569

Caroline Hayward (C)

SCALLOP consortium.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
ORCID: 0000-0002-9405-9550

Ulf Gyllensten (U)

SCALLOP consortium.
Department of Immunology, Genetics, and Pathology, Biomedical Center, Science for Life Laboratory (SciLifeLab) Uppsala University, Uppsala, Sweden.

Mikael Landen (M)

SCALLOP consortium.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
ORCID: 0000-0002-4496-6451

Agneta Siegbahn (A)

SCALLOP consortium.
Department of Medical Sciences, Clinical Chemistry, Uppsala University, Uppsala, Sweden.

James F Wilson (JF)

SCALLOP consortium.
MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, Scotland.
Centre for Global Health Research, Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.

Lars Wallentin (L)

SCALLOP consortium.
Department of Medical Sciences, Cardiology and Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden.

Adam S Butterworth (AS)

SCALLOP consortium.
BHF Cardiovascular Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Health Data Research UK Cambridge, Wellcome Genome Campus and University of Cambridge, Cambridge, UK.
British Heart Foundation Centre of Research Excellence, University of Cambridge, Cambridge, UK.
National Institute for Health Research Blood and Transplant Research Unit in Donor Health and Genomics, University of Cambridge, Cambridge, UK.
National Institute for Health Research Cambridge Biomedical Research Centre, University of Cambridge and Cambridge University Hospitals, Cambridge, UK.
ORCID: 0000-0002-6915-9015

Michael V Holmes (MV)

SCALLOP consortium.
Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK.
ORCID: 0000-0001-6617-0879

Erik Ingelsson (E)

SCALLOP consortium.
Department of Medicine, Division of Cardiovascular Medicine, Falk Cardiovascular Research Center, Stanford University School of Medicine, Stanford, CA, USA.
ORCID: 0000-0003-2256-6972

Anders Mälarstig (A)

Department of Medicine, Karolinska Institute, Solna, Sweden. anders.malarstig@ki.se.
SCALLOP consortium, . anders.malarstig@ki.se.
Emerging Science & Innovation, Pfizer Worldwide Research, Development and Medical, Cambridge, MA, USA. anders.malarstig@ki.se.
ORCID: 0000-0003-2608-1358

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › Sous-famille A de transporteurs à cassette liant l'ATP › Membre-1 de la sous-famille A des transporteurs à cassette liant l'ATP › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Maladies du système immunitaire › Hypersensibilité › Hypersensibilité immédiate › Hypersensibilité respiratoire › Asthme › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Système cardiovasculaire › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Cartographie chromosomique › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Ciblage de gène › Techniques de knock-down de gènes › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies inflammatoires intestinales › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux interleukines › Récepteurs à l'interleukine-1 › Protéine-1 analogue au récepteur de l'interleukin-1 › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Phénomènes génétiques › Liaison génétique › Déséquilibre de liaison › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Techniques d'investigation › Analyse de randomisation mendélienne › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéome › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Locus génétiques › Locus de caractère quantitatif › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux chimiokines › Récepteurs CCR › Récepteurs CCR2 › Genomic and drug target evaluation of 90...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs viraux › Récepteur VIH › Récepteurs CCR5 › Genomic and drug target evaluation of 90...