Associations between early life stress and anterior pituitary gland volume development during late childhood.
Adverse Childhood Experiences
/ psychology
Child
Female
Humans
Hydrocortisone
/ analysis
Hypothalamo-Hypophyseal System
/ physiopathology
Magnetic Resonance Imaging
/ methods
Male
Parenting
/ psychology
Pituitary Gland, Anterior
/ anatomy & histology
Pituitary-Adrenal System
/ physiopathology
Saliva
/ chemistry
Stress, Psychological
/ physiopathology
Early life adversity
Hypothalamic pituitary adrenal axis
Internalizing symptoms
Parenting
Pituitary gland development
Stress
Journal
Psychoneuroendocrinology
ISSN: 1873-3360
Titre abrégé: Psychoneuroendocrinology
Pays: England
ID NLM: 7612148
Informations de publication
Date de publication:
12 2020
12 2020
Historique:
received:
18
04
2020
revised:
04
09
2020
accepted:
04
09
2020
pubmed:
18
10
2020
medline:
31
8
2021
entrez:
17
10
2020
Statut:
ppublish
Résumé
Early Life Stress (ELS) is thought to influence Hypothalamic-Pituitary-Adrenal-Axis (HPAA) functioning, contributing to an increased risk for psychopathology through dysregulation of biological stress responses. Research exploring relationships between ELS and HPAA functioning has largely focused on its key hormonal output, cortisol. However, findings have been inconsistent, potentially due to cortisol's distinctive diurnal patterns and dynamic nature complicating its accurate measurement. Thus, this study explored the link between ELS and a more stable, structural component of the HPAA, specifically, anterior pituitary gland volume (PGV) in a community sample of children (N = 129, 68 female). PGV was traced from Magnetic Resonance Imaging brain scans across two time-points at ages 8 (baseline) and 10 years (follow-up). ELS exposure was assessed at baseline through parent-report questionnaires and maternal affective behavior observed in mother-child interaction tasks. ELS variables were reduced to a 5-factor structure using exploratory factor analysis - Uninvolved Parenting, Negative Affective Parenting, Neglect, Trauma, and Dysfunctional Discipline. Direct and sex-moderated associations between ELS and PGV were explored using regression and linear mixed models analyses. PGV-mediated associations between ELS and internalizing symptoms were also investigated. Childhood Neglect was significantly associated with greater baseline anterior PGV, that was stable over the follow-up period. This effect was found in the whole sample, and in males, specifically. No mediation effects were found. Results suggest that neglect may play a unique role in HPAA neurodevelopment; however, it is important that future research extends into adolescence to more clearly characterize these neurodevelopmental associations and any subsequent psychopathological outcomes.
Identifiants
pubmed: 33068951
pii: S0306-4530(20)30291-2
doi: 10.1016/j.psyneuen.2020.104868
pii:
doi:
Substances chimiques
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104868Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.