Donor specific anti-HLA antibodies and cardiac allograft vasculopathy: A prospective study using highly automated 3-D optical coherence tomography analysis.
Cardiac allograft vasculopathy
Donor specific antibodies
Heart transplant
Intimal thickness
Journal
Transplant immunology
ISSN: 1878-5492
Titre abrégé: Transpl Immunol
Pays: Netherlands
ID NLM: 9309923
Informations de publication
Date de publication:
04 2021
04 2021
Historique:
received:
12
09
2020
revised:
12
10
2020
accepted:
12
10
2020
pubmed:
19
10
2020
medline:
14
1
2022
entrez:
18
10
2020
Statut:
ppublish
Résumé
Recent studies suggested potential positive correlations between HLA-specific antibodies and development of cardiac allograft vasculopathy (CAV). This prospective two-center study investigated early progression of CAV by coronary optical coherence tomography in 1 month and 12 months after heart transplantation (HTx) in 104 patients. Detection and characterization of donor specific (DSA) and MHC class-I polypeptide-related sequence A (MICA) antibodies were performed before, 1, 6 and 12 months after transplantation. During the first post-HTx year, we observed a significant reduction in the mean coronary luminal area (P < .001), and progression in mean intimal thickness (IT) (P < .001). DSA and anti-MICA occurred in 17% of all patients, but no significant relationship was observed between presence of DSA/anti-MICA and IT progression within 12 months after HTx. In contrast, we observed significant association between presence of DSA (p=0.031), de-novo DSA (p=0.031), HLA Class II DSA (p=0.017) and media thickness (MT) progression. Results of our study did not identify a direct association between presence of DSA/anti-MICA and intimal thickness progression in an early period after HTx. However, we found significant relationships between DSA and media thickness progression that may identify a newly recognized immune-pathological aspect of CAV.
Identifiants
pubmed: 33069814
pii: S0966-3274(20)30148-9
doi: 10.1016/j.trim.2020.101340
pmc: PMC9114443
mid: NIHMS1643461
pii:
doi:
Substances chimiques
HLA Antigens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
101340Subventions
Organisme : NIBIB NIH HHS
ID : R01 EB004640
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.
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