Inherently and Conditionally Essential Protein Catabolism Genes of Porphyromonas gingivalis.
Porphyromonas gingivalis
essential genes
fitness
pathogenesis
periodontitis
transposon sequencing
Journal
Trends in microbiology
ISSN: 1878-4380
Titre abrégé: Trends Microbiol
Pays: England
ID NLM: 9310916
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
20
03
2020
revised:
01
07
2020
accepted:
02
09
2020
pubmed:
20
10
2020
medline:
6
7
2021
entrez:
19
10
2020
Statut:
ppublish
Résumé
Proteases are critical virulence determinants of Porphyromonas gingivalis, an emerging Alzheimer's disease, cancer, and arthritis pathogen and established agent of periodontitis. Transposon sequencing has been employed to define the core essential genome of this bacterium and genes conditionally essential in multiple environments - abscess formation; epithelial colonization; and cigarette smoke toxin exposure; as well as to elucidate genes required for iron acquisition and a functional type 9 secretion system. Validated and predicted protein catabolism genes identified include a combination of established virulence factors and a larger set of seemingly more mundane proteolytic genes. The functions and relevance of genes that share essentiality in multiple disease-relevant conditions are examined. These common stress-related genes may represent particularly attractive therapeutic targets for the control of P. gingivalis infections.
Identifiants
pubmed: 33071035
pii: S0966-842X(20)30236-5
doi: 10.1016/j.tim.2020.09.002
pmc: PMC8208481
mid: NIHMS1708381
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Virulence Factors
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
54-64Subventions
Organisme : NIGMS NIH HHS
ID : P20 GM125504
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE017680
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE026963
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE028506
Pays : United States
Informations de copyright
Copyright © 2020 Elsevier Ltd. All rights reserved.
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