Hyper-Inflammatory Monocyte Activation Following Endotoxin Exposure in Food Allergic Infants.
Age Factors
Allergens
/ immunology
Biomarkers
CD4-Positive T-Lymphocytes
/ immunology
Cells, Cultured
Cytokines
/ biosynthesis
Disease Susceptibility
Egg Hypersensitivity
/ diagnosis
Endotoxins
/ adverse effects
Female
Food Hypersensitivity
/ diagnosis
Humans
Immunization
Immunoglobulin E
/ immunology
Immunophenotyping
Infant
Leukocytes, Mononuclear
/ immunology
Male
Monocytes
/ immunology
food allergy
inflammatory response
monocytes
regulatory T (Treg) cell
trained immunity
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
31
05
2020
accepted:
25
08
2020
entrez:
19
10
2020
pubmed:
20
10
2020
medline:
13
5
2021
Statut:
epublish
Résumé
Several recent studies have reported a key role for innate cell hyper-responsiveness in food allergy. This has predominantly been observed in early life, with evidence that innate immune function may return to baseline if food allergy resolves in later childhood. Hallmarks of hyper-responsiveness include increased circulating frequency of monocytes and altered innate cell cytokine responses to
Identifiants
pubmed: 33072108
doi: 10.3389/fimmu.2020.567981
pmc: PMC7541825
doi:
Substances chimiques
Allergens
0
Biomarkers
0
Cytokines
0
Endotoxins
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
567981Informations de copyright
Copyright © 2020 Neeland, Novakovic, Dang, Perrett, Koplin and Saffery.
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