Enrichment of genomic pathways based on differential DNA methylation profiles associated with chronic musculoskeletal pain in older adults: An exploratory study.

Activating Transcription Factor 2 / genetics Aged Antigen Presentation / genetics Apoptosis / genetics Chronic Pain / blood CpG Islands DNA Methylation Female Gene Expression Regulation / genetics Humans Interleukin-4 / genetics Male Musculoskeletal Pain / blood OX40 Ligand / genetics Programmed Cell Death 1 Receptor / genetics Receptors, GABA / metabolism Signal Transduction / genetics T-Lymphocytes / immunology
Chronic musculoskeletal pain DNA methylation gamma-aminobutyric acid genomic pathways immune signaling older adult

Journal

Molecular pain
ISSN: 1744-8069
Titre abrégé: Mol Pain
Pays: United States
ID NLM: 101242662

Informations de publication

Date de publication:
Historique:
entrez: 19 10 2020
pubmed: 20 10 2020
medline: 28 7 2021
Statut: ppublish

Résumé

Our study aimed to identify differentially methylated CpGs/regions and their enriched genomic pathways associated with underlying chronic musculoskeletal pain in older individuals. We recruited cognitively healthy older adults with (

Identifiants

DOI: 10.1177/1744806920966902 PMID: 33073674 PMC: PMC7711149
pubmed: 33073674
doi: 10.1177/1744806920966902
pmc: PMC7711149
doi:

Substances chimiques

ATF2 protein, human 0
Activating Transcription Factor 2 0
IL4 protein, human 0
OX40 Ligand 0
PDCD1 protein, human 0
Programmed Cell Death 1 Receptor 0
Receptors, GABA 0
TNFSF4 protein, human 0
Interleukin-4 207137-56-2

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

1744806920966902

Subventions

Organisme : NIA NIH HHS
ID : K01 AG048259
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG059809
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG067757
Pays : United States
Organisme : NIA NIH HHS
ID : T32 AG049673
Pays : United States

Références

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Auteurs

Soamy Montesino-Goicolea (S)

Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Department of Community Dentistry & Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL, USA.
ORCID: 0000-0002-0065-0236

Puja Sinha (P)

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.

Zhiguang Huo (Z)

Department of Biostatistics, College of Public Health & Health Professions and College of Medicine, University of Florida, Gainesville, FL, USA.

Asha Rani (A)

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.

Thomas C Foster (TC)

Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
Genetics and Genomics Program, University of Florida, Gainesville, FL, USA.
Institute on Aging, University of Florida, Gainesville, FL, USA.

Yenisel Cruz-Almeida (Y)

Pain Research & Intervention Center of Excellence, University of Florida, Gainesville, FL, USA.
Department of Community Dentistry & Behavioral Science, College of Dentistry, University of Florida, Gainesville, FL, USA.
ORCID: 0000-0002-0065-0236

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique et à glissière à leucines › Facteurs de transcription ATF › Facteur de transcription ATF-2 › Enrichment of genomic pathways based on...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › Immunité cellulaire › Présentation d'antigène › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Mort cellulaire › Mort cellulaire régulée › Apoptose › Enrichment of genomic pathways based on...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Douleur chronique › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Ilots CpG › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Enrichment of genomic pathways based on...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enrichment of genomic pathways based on...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Interleukines › Interleukine-4 › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Sensation › Douleur musculosquelettique › Enrichment of genomic pathways based on...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de OX40 › Enrichment of genomic pathways based on...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des lymphocytes T › Récepteur-1 de mort cellulaire programmée › Enrichment of genomic pathways based on...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs aux acides aminés › Récepteurs GABA › Enrichment of genomic pathways based on...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Enrichment of genomic pathways based on...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Enrichment of genomic pathways based on...