Interaction of macrocyclic gadolinium-based MR contrast agents with Type I collagen. Equilibrium and kinetic studies.
Animals
Cattle
Collagen Type I
/ chemistry
Contrast Media
/ chemistry
Coordination Complexes
/ chemistry
Gadolinium
/ chemistry
Heterocyclic Compounds
/ chemistry
Kinetics
Ligands
Macrocyclic Compounds
/ chemistry
Magnetic Resonance Imaging
/ methods
Meglumine
/ chemistry
Models, Molecular
Organometallic Compounds
/ chemistry
Rats
Structure-Activity Relationship
Thermodynamics
Journal
Dalton transactions (Cambridge, England : 2003)
ISSN: 1477-9234
Titre abrégé: Dalton Trans
Pays: England
ID NLM: 101176026
Informations de publication
Date de publication:
03 Nov 2020
03 Nov 2020
Historique:
pubmed:
20
10
2020
medline:
30
7
2021
entrez:
19
10
2020
Statut:
ppublish
Résumé
The interactions of gadoterate meglumine, gadobutrol, gadoteridol and Gd(HB-DO3A) with bovine Type I collagen were investigated by ultrafiltration and dialysis. The affinity of the four agents to collagen is similar. However, the maximum adsorbed amount of GdIII-complexes decreases in the following order: gadoterate meglumine > gadobutrol > gadoteridol > Gd(HB-DO3A). Calculations with the open three-compartment model reveal that the structural homologs gadoteridol and Gd(HB-DO3A) have a lower adsorption onto collagen, which may explain the less prolonged in vivo retention of gadoteridol observed in soft tissues of rats.
Substances chimiques
Collagen Type I
0
Contrast Media
0
Coordination Complexes
0
Heterocyclic Compounds
0
Ligands
0
Macrocyclic Compounds
0
Organometallic Compounds
0
gadoteridol
0199MV609F
gadobutrol
1BJ477IO2L
Meglumine
6HG8UB2MUY
Gadolinium
AU0V1LM3JT
gadoterate meglumine
L0ND3981AG
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM