Vanishing White Matter Hyperintensities in CADASIL: A Case Report with Insight into Disease Mechanisms.
Antimanic Agents
/ therapeutic use
Bipolar Disorder
/ complications
Brain
/ diagnostic imaging
CADASIL
/ complications
Disease Progression
Drug Substitution
Female
Humans
Imaging, Three-Dimensional
Leukoencephalopathies
/ diagnostic imaging
Lithium Compounds
/ therapeutic use
Magnetic Resonance Imaging
Middle Aged
Organ Size
Temporal Lobe
/ diagnostic imaging
Valproic Acid
/ analogs & derivatives
Brain volume
CADASIL
valpromide
white matter hyperintensities
Journal
Journal of Alzheimer's disease : JAD
ISSN: 1875-8908
Titre abrégé: J Alzheimers Dis
Pays: Netherlands
ID NLM: 9814863
Informations de publication
Date de publication:
2020
2020
Historique:
pubmed:
20
10
2020
medline:
28
9
2021
entrez:
19
10
2020
Statut:
ppublish
Résumé
In a woman with Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) followed for 15 years, we observed magnetic resonance imaging white matter hyperintensities that vanished in the anterior temporal poles while the brain volume decreased unexpectedly. These imaging changes were transient and detected when the patient was being treated by valproic acid for stabilizing mood disturbances. This intriguing case supports that mechanisms underlying white matter hyperintensities can vary from one brain area to another and that important modifications of water influx into the brain tissue might be involved in some imaging features of CADASIL.
Identifiants
pubmed: 33074242
pii: JAD201086
doi: 10.3233/JAD-201086
doi:
Substances chimiques
Antimanic Agents
0
Lithium Compounds
0
Valproic Acid
614OI1Z5WI
dipropylacetamide
RUA6CWU76G
Types de publication
Case Reports
Letter
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM