Phosphoproteomics Meets Chemical Genetics: Approaches for Global Mapping and Deciphering the Phosphoproteome.
chemical genetics
conditional ATP analog-sensitive mutants
mass spectrometry
phosphoproteomics
phosphorylation
protein kinase
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
15 Oct 2020
15 Oct 2020
Historique:
received:
18
09
2020
revised:
13
10
2020
accepted:
14
10
2020
entrez:
20
10
2020
pubmed:
21
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Protein kinases are important enzymes involved in the regulation of various cellular processes. To function properly, each protein kinase phosphorylates only a limited number of proteins among the thousands present in the cell. This provides a rapid and dynamic regulatory mechanism that controls biological functions of the proteins. Despite the importance of protein kinases, most of their substrates remain unknown. Recently, the advances in the fields of protein engineering, chemical genetics, and mass spectrometry have boosted studies on identification of bona fide substrates of protein kinases. Among the various methods in protein kinase specific substrate identification, genetically engineered protein kinases and quantitative phosphoproteomics have become promising tools. Herein, we review the current advances in the field of chemical genetics in analog-sensitive protein kinase mutants and highlight selected strategies for identifying protein kinase substrates and studying the dynamic nature of protein phosphorylation.
Identifiants
pubmed: 33076458
pii: ijms21207637
doi: 10.3390/ijms21207637
pmc: PMC7588962
pii:
doi:
Substances chimiques
Phosphoproteins
0
Proteome
0
Protein Kinases
EC 2.7.-
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Agentúra Ministerstva Školstva, Vedy, Výskumu a Športu SR
ID : APVV-16-0120
Organisme : Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
ID : 2/0026/18
Organisme : Ministerstvo školstva, vedy, výskumu a športu Slovenskej republiky
ID : 2/0039/19
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