Prediction of the treatment response in ovarian cancer: a ctDNA approach.


Journal

Journal of ovarian research
ISSN: 1757-2215
Titre abrégé: J Ovarian Res
Pays: England
ID NLM: 101474849

Informations de publication

Date de publication:
19 Oct 2020
Historique:
received: 22 07 2020
accepted: 11 10 2020
entrez: 20 10 2020
pubmed: 21 10 2020
medline: 24 7 2021
Statut: epublish

Résumé

Ovarian cancer is the eighth most commonly occurring cancer in women. Clinically, the limitation of conventional screening and monitoring approaches inhibits high throughput analysis of the tumor molecular markers toward prediction of treatment response. Recently, analysis of liquid biopsies including circulating tumor DNA (ctDNA) open new way toward cancer diagnosis and treatment in a personalized manner in various types of solid tumors. In the case of ovarian carcinoma, growing pre-clinical and clinical studies underscored promising application of ctDNA in diagnosis, prognosis, and prediction of treatment response. In this review, we accumulate and highlight recent molecular findings of ctDNA analysis and its associations with treatment response and patient outcome. Additionally, we discussed the potential application of ctDNA in the personalized treatment of ovarian carcinoma. ctDNA-monitoring usage during the ovarian cancer treatments procedures.

Identifiants

pubmed: 33076944
doi: 10.1186/s13048-020-00729-1
pii: 10.1186/s13048-020-00729-1
pmc: PMC7574472
doi:

Substances chimiques

Circulating Tumor DNA 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

124

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Auteurs

Mina Sharbatoghli (M)

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.

Somayeh Vafaei (S)

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran.

Hamidreza Aboulkheyr Es (H)

School of Biomedical Engineering, University of Technology Sydney, Sydney, 2007, Australia.

Mohsen Asadi-Lari (M)

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran.
Department of Epidemiology, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.

Mehdi Totonchi (M)

Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran. m.totonchi@royaninstitute.org.
Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. m.totonchi@royaninstitute.org.

Zahra Madjd (Z)

Oncopathology Research Center, Iran University of Medical Sciences, Tehran, Iran. Zahra.madjd@yahoo.com.
Department of Molecular Medicine, Faculty of Advanced Technologies in Medicine, Iran University of Medical Sciences, Tehran, Iran. Zahra.madjd@yahoo.com.

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