PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes, Which Is Critically Important in Cardiac Hypertrophy.
Animals
Cardiomegaly
/ metabolism
Cell Line
Gene Expression Regulation
HEK293 Cells
Humans
Male
Mitochondria, Heart
/ metabolism
Myocytes, Cardiac
/ metabolism
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
/ metabolism
Promoter Regions, Genetic
Protein Deglycase DJ-1
/ metabolism
Rats
Rats, Sprague-Dawley
Repressor Proteins
/ metabolism
Sumoylation
Transcription Factors
/ metabolism
SUMOylation
cardiac hypertrophy
mitochondria
mitochondrial dysfunction
oxidative stress
transcriptional repression
Journal
Molecular and cellular biology
ISSN: 1098-5549
Titre abrégé: Mol Cell Biol
Pays: United States
ID NLM: 8109087
Informations de publication
Date de publication:
21 12 2020
21 12 2020
Historique:
received:
18
03
2020
accepted:
05
10
2020
pubmed:
21
10
2020
medline:
12
2
2021
entrez:
20
10
2020
Statut:
epublish
Résumé
Mitochondrial dysfunction is one of the major pathological attributes of cardiac hypertrophy and is associated with reduced expression of PGC1α in cardiomyocytes. However, the transcriptional regulation of PGC1α remains elusive. Here, we show that parkin interacting substrate (PARIS), a KRAB zinc finger protein, prevented PGC1α transcription despite the induction of cardiomyocytes with hypertrophic stimuli. Moreover, PARIS expression and its nuclear localization are enhanced in hypertrophy both
Identifiants
pubmed: 33077496
pii: MCB.00106-20
doi: 10.1128/MCB.00106-20
pmc: PMC7849400
pii:
doi:
Substances chimiques
PPARGC1A protein, human
0
Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
0
Ppargc1a protein, rat
0
Repressor Proteins
0
Transcription Factors
0
ZNF746 protein, human
0
PARK7 protein, human
EC 3.1.2.-
PARK7 protein, rat
EC 3.1.2.-
Protein Deglycase DJ-1
EC 3.1.2.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 American Society for Microbiology.
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