JuSpace: A tool for spatial correlation analyses of magnetic resonance imaging data with nuclear imaging derived neurotransmitter maps.
Cerebrovascular Circulation
/ drug effects
Humans
Magnetic Resonance Imaging
Neuroimaging
/ methods
Neurotransmitter Agents
/ pharmacology
Parkinson Disease
/ diagnostic imaging
Positron-Emission Tomography
Receptors, Neurotransmitter
/ drug effects
Synaptic Transmission
/ physiology
Tomography, Emission-Computed, Single-Photon
Parkinson's disease
magnetic resonance imaging
neuroimaging
neuropharmacology
neurotransmission
positron emission tomography
Journal
Human brain mapping
ISSN: 1097-0193
Titre abrégé: Hum Brain Mapp
Pays: United States
ID NLM: 9419065
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
15
06
2020
revised:
02
10
2020
accepted:
05
10
2020
pubmed:
21
10
2020
medline:
28
12
2021
entrez:
20
10
2020
Statut:
ppublish
Résumé
Recent studies have shown that drug-induced spatial alteration patterns in resting state functional activity as measured using magnetic resonance imaging (rsfMRI) are associated with the distribution of specific receptor systems targeted by respective compounds. Based on this approach, we introduce a toolbox (JuSpace) allowing for cross-modal correlation of MRI-based measures with nuclear imaging derived estimates covering various neurotransmitter systems including dopaminergic, serotonergic, noradrenergic, and GABAergic (gamma-aminobutric acid) neurotransmission. We apply JuSpace to two datasets covering Parkinson's disease patients (PD) and risperidone-induced changes in rsfMRI and cerebral blood flow (CBF). Consistently with the predominant neurodegeneration of dopaminergic and serotonergic system in PD, we find significant spatial associations between rsfMRI activity alterations in PD and dopaminergic (D2) and serotonergic systems (5-HT1b). Risperidone induced CBF alterations were correlated with its main targets in serotonergic and dopaminergic systems. JuSpace provides a biologically meaningful framework for linking neuroimaging to underlying neurotransmitter information.
Identifiants
pubmed: 33079453
doi: 10.1002/hbm.25244
pmc: PMC7814756
doi:
Substances chimiques
Neurotransmitter Agents
0
Receptors, Neurotransmitter
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
555-566Informations de copyright
© 2020 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Références
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1025-1032
pubmed: 28197685
J Cereb Blood Flow Metab. 2015 Jul;35(7):1199-205
pubmed: 25853904
Nat Rev Neurosci. 2006 Oct;7(10):818-27
pubmed: 16988657
Neuroimage. 2012 Oct 15;63(1):447-59
pubmed: 22789740
Neuroimage. 2002 Jan;15(1):273-89
pubmed: 11771995
Hum Brain Mapp. 2021 Feb 15;42(3):555-566
pubmed: 33079453
PLoS One. 2018 Nov 8;13(11):e0206583
pubmed: 30408072
Hum Brain Mapp. 2018 Jan;39(1):319-331
pubmed: 29058358
Brain Res Rev. 2008 Jun;58(1):209-25
pubmed: 18486229
Cereb Cortex. 2020 May 18;30(6):3771-3780
pubmed: 31989157
Sci Rep. 2018 Mar 6;8(1):4074
pubmed: 29511260
Psychopharmacology (Berl). 2015 Nov;232(21-22):4169-78
pubmed: 25918111
Psychopharmacology (Berl). 1996 Mar;124(1-2):57-73
pubmed: 8935801
AJNR Am J Neuroradiol. 2013 Oct;34(10):1866-72
pubmed: 22936095
Bioinformatics. 2019 Oct 1;35(19):3771-3778
pubmed: 30854545
Neuroimage. 2019 Mar;188:774-784
pubmed: 30553916
Sci Transl Med. 2019 Feb 27;11(481):
pubmed: 30814340
J Alzheimers Dis. 2011;26(4):627-45
pubmed: 21694448
Mol Psychiatry. 2016 Apr;21(4):547-53
pubmed: 26033243
PLoS One. 2018 Jun 22;13(6):e0198349
pubmed: 29933375
Brain Imaging Behav. 2014 Jun;8(2):153-82
pubmed: 24399358
J Neurosci. 2017 Jan 4;37(1):120-128
pubmed: 28053035
Neuroimage. 2001 Jul;14(1 Pt 1):21-36
pubmed: 11525331
Eur J Nucl Med Mol Imaging. 2017 Jun;44(6):1056-1064
pubmed: 28066877
Front Neuroinform. 2010 Dec 08;4:117
pubmed: 21165174
Nat Med. 2017 Jan;23(1):28-38
pubmed: 27918562
Synapse. 1998 Dec;30(4):380-92
pubmed: 9826230
J Cereb Blood Flow Metab. 2001 Sep;21(9):1034-57
pubmed: 11524609
Neuroimage. 2015 Jun;113:111-21
pubmed: 25791784
PLoS One. 2016 Feb 16;11(2):e0148744
pubmed: 26882227
J Neurosci. 2001 Sep 1;21(17):6502-11
pubmed: 11517239
Ann Neurol. 2017 Feb;81(2):171-180
pubmed: 28019672
Neuropsychopharmacology. 2005 Sep;30(9):1741-50
pubmed: 15841106
J Neurol Neurosurg Psychiatry. 1997 Feb;62(2):133-40
pubmed: 9048712
Magn Reson Imaging. 2008 May;26(4):490-503
pubmed: 18060720
Neurology. 2010 Jun 1;74(22):1776-84
pubmed: 20513813
Transl Psychiatry. 2020 Mar 20;10(1):100
pubmed: 32198361