Interaction between high-density lipoproteins and inflammation: Function matters more than concentration!

Animals Apolipoprotein A-I / metabolism Humans Immune System Diseases / metabolism Inflammation / metabolism Lipoproteins, HDL / metabolism Protein Processing, Post-Translational
Auto-immune diseases Chronic kidney disease High-density lipoproteins Infectious diseases Inflammation Metabolic diseases Neurological diseases

Journal

Advanced drug delivery reviews
ISSN: 1872-8294
Titre abrégé: Adv Drug Deliv Rev
Pays: Netherlands
ID NLM: 8710523

Informations de publication

Date de publication:
2020
Historique:
received: 06 01 2020
revised: 20 09 2020
accepted: 13 10 2020
pubmed: 21 10 2020
medline: 28 8 2021
entrez: 20 10 2020
Statut: ppublish

Résumé

High-density lipoprotein (HDL) plays an important role in lipid metabolism and especially contributes to the reverse cholesterol transport pathway. Over recent years it has become clear that the effect of HDL on immune-modulation is not only dependent on HDL concentration but also and perhaps even more so on HDL function. This review will provide a concise general introduction to HDL followed by an overview of post-translational modifications of HDL and a detailed overview of the role of HDL in inflammatory diseases. The clinical potential of HDL and its main apolipoprotein constituent, apoA-I, is also addressed in this context. Finally, some conclusions and remarks that are important for future HDL-based research and further development of HDL-focused therapies are discussed.

Identifiants

DOI: 10.1016/j.addr.2020.10.006 PMID: 33080259
pubmed: 33080259
pii: S0169-409X(20)30143-5
doi: 10.1016/j.addr.2020.10.006
pii:
doi:

Substances chimiques

APOA1 protein, human 0
Apolipoprotein A-I 0
Lipoproteins, HDL 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

94-119

Informations de copyright

Copyright © 2020 The Authors. Published by Elsevier B.V. All rights reserved.

Auteurs

Sumra Nazir (S)

Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany.

Vera Jankowski (V)

Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany.

Guzide Bender (G)

Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany.

Stephen Zewinger (S)

Department of Internal Medicine 4, Nephrology and Hypertension, Saarland University Medical Centre, Homburg, Germany; Department of Nephrology, Hôpitaux Robert Schuman, Hôpital Kirchberg, Luxembourg, Luxembourg.

Kerry-Anne Rye (KA)

Lipid Research Group, School of Medical Sciences, The University of New South Wales Sydney, New South Wales, Australia.

Emiel P C van der Vorst (EPC)

Institute for Molecular Cardiovascular Research (IMCAR), RWTH Aachen University, Aachen, Germany; Interdisciplinary Center for Clinical Research (IZKF), RWTH Aachen University, Aachen, Germany; Department of Pathology, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Medical Centre, Maastricht, Netherlands; Institute for Cardiovascular Prevention (IPEK), Ludwig-Maximilians-University Munich, Munich, Germany; German Centre for Cardiovascular Research (DZHK), Partner site Munich Heart Alliance, Munich, Germany. Electronic address: evandervorst@ukaachen.de.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Interaction between high-density lipoproteins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines A › Apolipoprotéine A-I › Interaction between high-density lipoproteins...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interaction between high-density lipoproteins...
questionsmedicales.fr › Maladies du système immunitaire › Interaction between high-density lipoproteins...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Interaction between high-density lipoproteins...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Interaction between high-density lipoproteins...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Interaction between high-density lipoproteins...