Fenugreek Stimulates the Expression of Genes Involved in Milk Synthesis and Milk Flow through Modulation of Insulin/GH/IGF-1 Axis and Oxytocin Secretion.
fenugreek
galactagogue
gene expression
insulin
lactating mammary gland
milk synthesis
oxytocin
pituitary gland
Journal
Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097
Informations de publication
Date de publication:
16 10 2020
16 10 2020
Historique:
received:
18
09
2020
revised:
06
10
2020
accepted:
13
10
2020
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
17
7
2021
Statut:
epublish
Résumé
We previously demonstrated galactagogue effect of fenugreek in a rat model of lactation challenge, foreshadowing its use in women's breastfeeding management. To assess longitudinal molecular mechanisms involved in milk synthesis/secretion in dams submitted to fenugreek supplementation, inguinal mammary, pituitary glands and plasma were isolated in forty-three rats nursing large 12 pups-litters and assigned to either a control (CTL) or a fenugreek-supplemented (FEN) diet during lactation. RT-PCR were performed at days 12 and 18 of lactation (L12 and L18) and the first day of involution (Inv1) to measure the relative expression of genes related to both milk synthesis and its regulation in the mammary gland and lactogenic hormones in the pituitary gland. Plasma hormone concentrations were measured by ELISA. FEN diet induced 2- to 3-times higher fold change in relative expression of several genes related to macronutrient synthesis (
Identifiants
pubmed: 33081164
pii: genes11101208
doi: 10.3390/genes11101208
pmc: PMC7602737
pii:
doi:
Substances chimiques
Insulin
0
Milk Proteins
0
Plant Extracts
0
Oxytocin
50-56-6
Insulin-Like Growth Factor I
67763-96-6
fenugreek seed meal
68990-15-8
Growth Hormone
9002-72-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
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