Valeric Acid Protects Dopaminergic Neurons by Suppressing Oxidative Stress, Neuroinflammation and Modulating Autophagy Pathways.
Animals
Antioxidants
/ pharmacology
Antiparkinson Agents
/ pharmacology
Apoptosis
Astrocytes
/ drug effects
Autophagy
Corpus Striatum
/ drug effects
Dopaminergic Neurons
/ drug effects
Male
Oxidative Stress
Parkinson Disease
/ drug therapy
Pentanoic Acids
/ pharmacology
Rats
Rats, Wistar
Ribosomal Protein S6 Kinases, 70-kDa
/ metabolism
Rotenone
/ toxicity
TOR Serine-Threonine Kinases
/ metabolism
Uncoupling Agents
/ toxicity
alpha-Synuclein
/ genetics
Parkinson’s disease
neuroinflammation
neuroprotection
oxidative stress
rotenone
valeric acid
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
16 Oct 2020
16 Oct 2020
Historique:
received:
26
08
2020
revised:
14
09
2020
accepted:
15
09
2020
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
26
2
2021
Statut:
epublish
Résumé
Parkinson's disease, the second common neurodegenerative disease is clinically characterized by degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc) with upregulation of neuroinflammatory markers and oxidative stress. Autophagy lysosome pathway (ALP) plays a major role in degradation of damaged organelles and proteins for energy balance and intracellular homeostasis. However, dysfunction of ALP results in impairment of α-synuclein clearance which hastens dopaminergic neurons loss. In this study, we wanted to understand the neuroprotective efficacy of Val in rotenone induced PD rat model. Animals received intraperitoneal injections (2.5 mg/kg) of rotenone daily followed by Val (40 mg/kg, i.p) for four weeks. Valeric acid, a straight chain alkyl carboxylic acid found naturally in
Identifiants
pubmed: 33081327
pii: ijms21207670
doi: 10.3390/ijms21207670
pmc: PMC7589299
pii:
doi:
Substances chimiques
Antioxidants
0
Antiparkinson Agents
0
Pentanoic Acids
0
Uncoupling Agents
0
alpha-Synuclein
0
Rotenone
03L9OT429T
Ribosomal Protein S6 Kinases, 70-kDa
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
n-pentanoic acid
GZK92PJM7B
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : College of Medicine and Health Sciences, United Arab Emirates University
ID : UPAR 31M234
Références
Neurobiol Dis. 2010 Mar;37(3):510-8
pubmed: 19913097
J Neuroimmune Pharmacol. 2015 Dec;10(4):561-75
pubmed: 26018603
Science. 2004 Aug 27;305(5688):1292-5
pubmed: 15333840
Neurobiol Aging. 2014 May;35(5):1116-24
pubmed: 24360742
Pharmacol Biochem Behav. 2003 Jun;75(3):537-45
pubmed: 12895671
J Neurochem. 2001 Jan;76(2):637-40
pubmed: 11208927
Ann N Y Acad Sci. 2003 Jun;991:214-28
pubmed: 12846989
ACS Chem Neurosci. 2012 Dec 19;3(12):1063-72
pubmed: 23259041
Exp Neurol. 2008 Jan;209(1):5-11
pubmed: 17603039
Toxicol Sci. 2019 Jun 1;169(2):333-352
pubmed: 30796443
Exp Neurol. 2012 Oct;237(2):318-34
pubmed: 22750327
Am J Pathol. 2009 Aug;175(2):736-47
pubmed: 19628769
Brain Res Brain Res Rev. 2005 Apr;48(2):196-206
pubmed: 15850658
Eur J Neurosci. 2000 Aug;12(8):3073-7
pubmed: 10971650
Ageing Int. 2017;42(3):274-289
pubmed: 28890585
Science. 2004 May 28;304(5675):1328-31
pubmed: 15105460
Neurosci Lett. 1994 Jan 3;165(1-2):208-10
pubmed: 8015728
Mov Disord. 2011 Jan;26(1):6-17
pubmed: 21322014
Neurobiol Dis. 2006 May;22(2):404-20
pubmed: 16439141
Neuroscience. 2015 Aug 27;302:47-58
pubmed: 25684748
Trends Mol Med. 2011 Dec;17(12):734-42
pubmed: 21890410
J Neurosci. 2005 Apr 6;25(14):3701-11
pubmed: 15814801
Neurobiol Dis. 2009 Sep;35(3):385-98
pubmed: 19505575
Trends Neurosci. 2010 Dec;33(12):541-9
pubmed: 20947179
Curr Opin Cell Biol. 2011 Apr;23(2):190-7
pubmed: 21087849
J Neurosci. 2006 Sep 27;26(39):9996-10005
pubmed: 17005863
Mol Cell Neurosci. 2000 Dec;16(6):724-39
pubmed: 11124893
J Neurochem. 1990 Dec;55(6):2142-5
pubmed: 2121905
FASEB J. 2007 Jan;21(1):179-87
pubmed: 17116747
Neurobiol Aging. 2003 Mar-Apr;24(2):197-211
pubmed: 12498954
FASEB J. 2002 Nov;16(13):1826-8
pubmed: 12223445
Neuron. 2009 Oct 15;64(1):110-22
pubmed: 19840553
J Cell Sci. 2007 Dec 1;120(Pt 23):4155-66
pubmed: 18032788
Toxicol Sci. 2015 Jan;143(1):81-96
pubmed: 25304210
Sci Rep. 2016 Aug 24;6:32206
pubmed: 27553905
J Neurochem. 2005 Jul;94(1):215-25
pubmed: 15953364
Nat Rev Neurosci. 2007 Jan;8(1):57-69
pubmed: 17180163
Cell Cycle. 2014;13(9):1400-12
pubmed: 24626186
IUBMB Life. 2001 Sep-Nov;52(3-5):135-41
pubmed: 11798025
J Neurol Sci. 1997 May 29;148(2):181-6
pubmed: 9129114
Front Mol Neurosci. 2014 Mar 14;7:18
pubmed: 24672426
Prog Neurobiol. 2012 Nov;99(2):128-48
pubmed: 22980037
Cell Signal. 2014 Dec;26(12):2694-701
pubmed: 25173700
Biochim Biophys Acta. 2012 May;1820(5):595-600
pubmed: 21846491
Brain Pathol. 2003 Oct;13(4):473-81
pubmed: 14655753
Neurology. 2017 Feb 21;88(8):767-774
pubmed: 28108638
Epilepsia. 2007 Apr;48(4):617-30
pubmed: 17386056
Epilepsy Res. 1990 Aug;6(3):249-51
pubmed: 1980246
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7659-63
pubmed: 9636206
Neurosci Lett. 1994 Oct 24;180(2):147-50
pubmed: 7700568
Handb Clin Neurol. 2007;83:535-51
pubmed: 18808933
J Neuroinflammation. 2010 Aug 11;7:45
pubmed: 20701773
Sci Rep. 2017 Mar 03;7:43153
pubmed: 28256519
BMC Neurosci. 2016 Aug 22;17(1):58
pubmed: 27549180
Acta Neuropathol. 2000 Jan;99(1):14-20
pubmed: 10651022
Histol Histopathol. 1997 Jan;12(1):25-31
pubmed: 9046040
Mol Neurobiol. 2012 Dec;46(3):639-61
pubmed: 22899187
Neurochem Int. 2013 Apr;62(5):803-19
pubmed: 23291248
J Neurosci. 1999 May 1;19(9):3440-7
pubmed: 10212304
J Neurol Sci. 1996 May;137(2):120-3
pubmed: 8782165
Neurogenetics. 2007 Apr;8(2):83-94
pubmed: 17211632
Biochem Biophys Res Commun. 1991 Dec 31;181(3):1442-8
pubmed: 1764096
Neurotherapeutics. 2010 Oct;7(4):413-23
pubmed: 20880505
Neuropathology. 2007 Oct;27(5):494-506
pubmed: 18018486
PLoS One. 2009;4(5):e5515
pubmed: 19436756
Mol Neurobiol. 2017 Sep;54(7):4866-4878
pubmed: 27514753
Exp Neurol. 2005 Jun;193(2):279-90
pubmed: 15869932
Proc Natl Acad Sci U S A. 2002 Jan 8;99(1):467-72
pubmed: 11756682
Neurochem Res. 2013 Jan;38(1):201-7
pubmed: 23117422
J Neurochem. 1989 Sep;53(3):692-7
pubmed: 2760616
J Parkinsons Dis. 2013;3(4):461-91
pubmed: 24252804
Cell Signal. 2014 Aug;26(8):1680-1689
pubmed: 24726895
Nutr Res Rev. 2000 Jun;13(1):47-77
pubmed: 19087433
Nat Rev Drug Discov. 2011 May;10(5):377-93
pubmed: 21532567
Nat Neurosci. 2000 Dec;3(12):1301-6
pubmed: 11100151