Associations of site-specific CD4

Adult CD4-Positive T-Lymphocytes / metabolism CD40 Ligand / genetics Cross-Sectional Studies DNA Methylation Female Humans Linear Models Lupus Erythematosus, Systemic / diagnosis Middle Aged Promoter Regions, Genetic / genetics Severity of Illness Index Trans-Activators / genetics
CD40-ligand Systemic lupus erythematosus T-cells disease activity epigenetics methylation

Journal

Lupus
ISSN: 1477-0962
Titre abrégé: Lupus
Pays: England
ID NLM: 9204265

Informations de publication

Date de publication:
01 2021
Historique:
pubmed: 22 10 2020
medline: 31 8 2021
entrez: 21 10 2020
Statut: ppublish

Résumé

To comprehensively assess associations of site-specific CD4 CpG-sites within the DNA of the promotor and two enhancer regions (n = 22) of 60 female SLE patients participated in the study (age 45.7 ± 11.1 years, disease duration 17.0 ± 8.3 years). Significant associations to the SLEDAI were noted for CpG22 hypomethylation of the promotor (β = -40.1, p = 0.017, adjusted p = 0.027), trends were noted for CpG17 hypomethylation of the promotor (β = -30.5, p = 0.032, adjusted p = 0.6), and for CpG11 hypermethylation of the second enhancer (β = 15.0, p = 0.046, adjusted p = 0.8). Site-specific hypomethylation of the

Identifiants

DOI: 10.1177/0961203320965690 PMID: 33081589
pubmed: 33081589
doi: 10.1177/0961203320965690
doi:

Substances chimiques

CXXC1 protein, human 0
Trans-Activators 0
CD40 Ligand 147205-72-9

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

45-51

Auteurs

Stefan Vordenbäumen (S)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.
Rheinisches Rheuma-Zentrum St. Elisabeth-Hospital, Meerbusch-Lank, Germany.
ORCID: 0000-0001-5725-5483

Anna Rosenbaum (A)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Claudia Gebhard (C)

Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany

Johanna Raithel (J)

Rheinisches Rheuma-Zentrum St. Elisabeth-Hospital, Meerbusch-Lank, Germany.
Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.

Alexander Sokolowski (A)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Christina Düsing (C)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Gamal Chehab (G)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Jutta G Richter (JG)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Ralph Brinks (R)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

Michael Rehli (M)

Department of Internal Medicine III, Hematology and Oncology, University Hospital Regensburg, Regensburg, Germany.
Regensburg Center for Interventional Immunology (RCI), Regensburg, Germany

Matthias Schneider (M)

Medical Faculty, Department & Hiller Research Unit for Rheumatology, Heinrich-Heine-University, Düsseldorf, Germany.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Associations of site-specific CD4
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › Associations of site-specific CD4
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de CD40 › Associations of site-specific CD4
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Associations of site-specific CD4
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Associations of site-specific CD4
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Associations of site-specific CD4
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › Modèles linéaires › Associations of site-specific CD4
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Associations of site-specific CD4
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Associations of site-specific CD4
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Régions promotrices (génétique) › Associations of site-specific CD4
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Associations of site-specific CD4
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Associations of site-specific CD4