The ZIP Code of Vesicle Trafficking in Apicomplexa: SEC1/Munc18 and SNARE Proteins.
Apicomplexa
Plasmodium falciparum
SEC1/Munc18
SNARE
Toxoplasma gondii
Vps45
apicomplexan parasites
apicoplast
exocytosis
inner membrane complex
membrane fusion
microneme
pellicle
rhoptry
small GTPases
syntaxin
Journal
mBio
ISSN: 2150-7511
Titre abrégé: mBio
Pays: United States
ID NLM: 101519231
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
20
7
2021
Statut:
epublish
Résumé
Apicomplexans are obligate intracellular parasites harboring three sets of unique secretory organelles termed micronemes, rhoptries, and dense granules that are dedicated to the establishment of infection in the host cell. Apicomplexans rely on the endolysosomal system to generate the secretory organelles and to ingest and digest host cell proteins. These parasites also possess a metabolically relevant secondary endosymbiotic organelle, the apicoplast, which relies on vesicular trafficking for correct incorporation of nuclear-encoded proteins into the organelle. Here, we demonstrate that the trafficking and destination of vesicles to the unique and specialized parasite compartments depend on SNARE proteins that interact with tethering factors. Specifically, all secreted proteins depend on the function of SLY1 at the Golgi. In addition to a critical role in trafficking of endocytosed host proteins, TgVps45 is implicated in the biogenesis of the inner membrane complex (alveoli) in both
Identifiants
pubmed: 33082261
pii: mBio.02092-20
doi: 10.1128/mBio.02092-20
pmc: PMC7587439
pii:
doi:
Substances chimiques
Munc18 Proteins
0
Protozoan Proteins
0
SNARE Proteins
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 Bisio et al.
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