Interclass GPCR heteromerization affects localization and trafficking.
Amino Acids
/ pharmacology
Animals
Bridged Bicyclo Compounds, Heterocyclic
/ pharmacology
Cell Membrane
/ metabolism
Clozapine
/ pharmacology
Endosomes
/ metabolism
HEK293 Cells
Humans
Mice, 129 Strain
Mice, Knockout
Microscopy, Confocal
Multiprotein Complexes
/ chemistry
Protein Multimerization
Protein Transport
/ drug effects
Receptor, Serotonin, 5-HT2A
/ chemistry
Receptors, Metabotropic Glutamate
/ chemistry
Serotonin Antagonists
/ pharmacology
Signal Transduction
Journal
Science signaling
ISSN: 1937-9145
Titre abrégé: Sci Signal
Pays: United States
ID NLM: 101465400
Informations de publication
Date de publication:
20 10 2020
20 10 2020
Historique:
entrez:
21
10
2020
pubmed:
22
10
2020
medline:
30
10
2021
Statut:
epublish
Résumé
Membrane trafficking processes regulate G protein-coupled receptor (GPCR) activity. Although class A GPCRs are capable of activating G proteins in a monomeric form, they can also potentially assemble into functional GPCR heteromers. Here, we showed that the class A serotonin 5-HT
Identifiants
pubmed: 33082287
pii: 13/654/eaaw3122
doi: 10.1126/scisignal.aaw3122
pmc: PMC7717648
mid: NIHMS1647483
pii:
doi:
Substances chimiques
Amino Acids
0
Bridged Bicyclo Compounds, Heterocyclic
0
LY 379268
0
Multiprotein Complexes
0
Receptor, Serotonin, 5-HT2A
0
Receptors, Metabotropic Glutamate
0
Serotonin Antagonists
0
metabotropic glutamate receptor 2
0
Clozapine
J60AR2IKIC
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK046943
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH111940
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM119617
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH084894
Pays : United States
Organisme : NIMH NIH HHS
ID : F30 MH116550
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH103455
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
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