Absence of relationships between depression and anxiety and bone mineral density in patients hospitalized for severe anorexia nervosa.
Anorexia nervosa
Anxiety
Bone mineral density
Compulsive disorders
Depression
Obsessive
Osteoporosis
Journal
Eating and weight disorders : EWD
ISSN: 1590-1262
Titre abrégé: Eat Weight Disord
Pays: Germany
ID NLM: 9707113
Informations de publication
Date de publication:
Aug 2021
Aug 2021
Historique:
received:
03
06
2020
accepted:
03
10
2020
pubmed:
22
10
2020
medline:
23
7
2021
entrez:
21
10
2020
Statut:
ppublish
Résumé
Low BMD is frequent in anorexia nervosa (AN), depression, and during SSRI treatment but relation between these elements in AN is not established. The aims of this study were to assess the relationships between depression and anxiety, SSRI prescription, and (1) low BMD during inpatient treatment and (2) BMD change 1 year after hospital discharge. From 2009 to 2011, 212 women with severe AN have been included in the EVHAN study (EValuation of Hospitalisation for AN). Depression, anxiety and obsessive-compulsive symptoms and comorbidity were evaluated using psychometric scales and CIDI-SF. BMD was measured by dual-energy X-ray absorptiometry. According to the CIDI-SF, 56% of participants (n = 70) had a lifetime major depressive disorder, 27.2% (n = 34) had a lifetime obsessive-compulsive disorder, 32.8% (n = 41) had a lifetime generalized anxiety disorder and 25.6% (n = 32) had a lifetime social phobia disorder. Half of the sample (50.7%; n = 72) had a low BMD (Z score ≤ - 2). In multivariate analysis, lifetime lowest BMI was the only determinant significantly associated with low BMD (OR = 0.56, p = 0.0008) during hospitalization. A long duration of AN (OR = 1.40 (0.003-3.92), p = 0.03), the AN-R subtype (OR = 4.95 (1.11-26.82), p = 0.04), an increase of BMI between the admission and 1 year (OR = 1.69 (1.21-2.60), p = 0.005) and a gain of BMD 1 year after the discharge explained BMD change. We did not find any association between depression and anxiety or SSRI treatment and a low BMD or variation of BMD. Level III, cohort study.
Identifiants
pubmed: 33085062
doi: 10.1007/s40519-020-01045-9
pii: 10.1007/s40519-020-01045-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1975-1984Informations de copyright
© 2020. Springer Nature Switzerland AG.
Références
Achamrah N, Coëffier M, Jésus P, Charles J, Rimbert A, Déchelotte P, Grigioni S (2017) Bone Mineral Density after Weight Gain in 160 Patients with Anorexia Nervosa. Frontiers in Nutrition 4:46. https://doi.org/10.3389/fnut.2017.00046
pubmed: 29034241
pmcid: 5626930
doi: 10.3389/fnut.2017.00046
Andrews G, Peters L (1998) The psychometric properties of the Composite International Diagnostic Interview. Soc Psychiatry Psychiatr Epidemiol 33(2):80–88. https://doi.org/10.1007/s001270050026
pubmed: 9503991
doi: 10.1007/s001270050026
Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J (1961) An inventory for measuring depression. Arch Gen Psychiatry 4:561–571
pubmed: 13688369
doi: 10.1001/archpsyc.1961.01710120031004
Biller BMK, Saxe V, Herzog DB, Rosenthal DI, Holzman S, Klibanski A (1989) Mechanisms of osteoporosis in adult and adolescent women with anorexia nervosa. J Clin Endocrinol Metabo 68(3):548–554. https://doi.org/10.1210/jcem-68-3-548
doi: 10.1210/jcem-68-3-548
Blanchet C, Guillaume S, Bat-Pitault F, Carles M-E, Clarke J, Dodin V, Godart N (2019) Medication in AN: a multidisciplinary overview of meta-analyses and systematic reviews. J Clin Med. https://doi.org/10.3390/jcm8020278
pubmed: 31374966
pmcid: 6723395
doi: 10.3390/jcm8020278
Bourque P, Beaudette D (1982) Étude psychometrique du questionnaire de dépression de Beck auprès d’un échantillon d’étudiants universitaires francophones. Psychometric study of the Beck Depression Inventory on a sample of French-speaking university students. Can J Behav Sci Revue Canadienne Des Sciences Du Comportement 14(3):211–218. https://doi.org/10.1037/h0081254
doi: 10.1037/h0081254
Cizza G, Primma S, Coyle M, Gourgiotis L, Csako G (2010) Depression and osteoporosis: a research synthesis with meta-analysis. Horm Metab Res Hormon- Und Stoffwechselforschung Hormones Et Metabolisme 42(7):467–482. https://doi.org/10.1055/s-0030-1252020
pubmed: 20455194
doi: 10.1055/s-0030-1252020
Cooper Z, Cooper PJ, Fairburn CG (1989) The validity of the eating disorder examination and its subscales. Br J Psychiatry J Mental Sci 154:807–812
doi: 10.1192/bjp.154.6.807
Di Giovanni F, de Medeiros JS, Santos Neto PH, Scuzziatto VA, Skare TL (2017) Depression and osteoporosis: a study of 100 patients. Prim Care Companion CNS Disord. https://doi.org/10.4088/PCC.16l02062
pubmed: 28534600
doi: 10.4088/PCC.16l02062
Fowler L, Blackwell A, Jaffa A, Palmer R, Robbins T, Sahakian B, Dowson J (2006) Profile of neurocognitive impairments associated with female in-patients with AN. Psychol Med 36:517–527. https://doi.org/10.1017/S0033291705006379
pubmed: 16318655
doi: 10.1017/S0033291705006379
Frølich J, Winkler LA, Abrahamsen B, Bilenberg N, Hermann AP, Støving RK (2020) Fractures in women with eating disorders-Incidence, predictive factors, and the impact of disease remission: cohort study with background population controls. Int J Eat Disord 53(7):1080–1087
pubmed: 31922277
doi: 10.1002/eat.23223
Giollo A, Idolazzi L, Caimmi C, Fassio A, Bertoldo F, Dalle Grave R, Gatti D (2017) Vitamin D levels strongly influence bone mineral density and bone turnover markers during weight gain in female patients with anorexia nervosa. The International Journal of Eating Disorders 50(9):1041–1049. https://doi.org/10.1002/eat.22731
pubmed: 28593655
doi: 10.1002/eat.22731
Godart NT, Perdereau F, Rein Z, Berthoz S, Wallier J, Jeammet P, Flament MF (2007) Comorbidity studies of eating disorders and mood disorders. Critical review of the literature. J Affect Disord 97(1–3):37–49. https://doi.org/10.1016/j.jad.2006.06.023
pubmed: 16926052
doi: 10.1016/j.jad.2006.06.023
Godart NT, Legleye S, Huas C, Coté SM, Choquet M, Falissard B, Touchette E (2013) Epidemiology of anorexia nervosa in a French community-based sample of 39,542 adolescents. Open J Epidemiol 03(02):53. https://doi.org/10.4236/ojepi.2013.32009
doi: 10.4236/ojepi.2013.32009
Goebel G, Schweiger U, Krüger R, Fichter MM (1999) Predictors of bone mineral density in patients with eating disorders. Int J Eat Disord 25:143–150
pubmed: 10065391
doi: 10.1002/(SICI)1098-108X(199903)25:2<143::AID-EAT3>3.0.CO;2-3
Hamrick MW, Della-Fera MA, Choi YH, Pennington C, Hartzell D, Baile CA (2005) Leptin treatment induces loss of bone marrow adipocytes and increases bone formation in leptin-deficient ob/ob mice. J Bone Miner Res 20:994–1001. https://doi.org/10.1359/JBMR.050103
pubmed: 15883640
doi: 10.1359/JBMR.050103
Hantouche E, Guelfi JD (1993) Self-evaluation of obsessive-compulsive disorder. Adaptation and validation of two psychometric scales to the French version. L’Encephale 19(3):241–248
pubmed: 8275910
Hebebrand J, Himmelmann GW, Heseker H, Schafer H, Remschmidt H (1996) Use of percentiles for the body mass index in anorexia nervosa: Diagnostic, epidemiological, and therapeutic considerations. The International Journal of Eating Disorders 19(4):359–369. https://doi.org/10.1002/(SICI)1098-108X(199605)19:4%3c359::AID-EAT4%3e3.0.CO;2-K
pubmed: 9156689
doi: 10.1002/(SICI)1098-108X(199605)19:4<359::AID-EAT4>3.0.CO;2-K
Hodgson RJ, Rachman S (1977) Obsessional-compulsive complaints. Behav Res Ther 15(5):389–395
pubmed: 612339
doi: 10.1016/0005-7967(77)90042-0
Jacoangeli F, Zoli A, Taranto A, Staar Mezzasalma F, Ficoneri C, Pierangeli S, Bollea MR (2002) Osteoporosis and anorexia nervosa: relative role of endocrine alterations and malnutrition. Eat Weight Disord EWD 7(3):190–195
pubmed: 12452250
doi: 10.1007/BF03327456
Kandemir N, Becker K, Slattery M, Tulsiani S, Singhal V, Thomas JJ, Misra M (2017) Impact of Low-Weight Severity and Menstrual Status on Bone in Adolescent Girls with Anorexia Nervosa. The International Journal of Eating Disorders 50(4):359–369. https://doi.org/10.1002/eat.22681
pubmed: 28152193
pmcid: 5386816
doi: 10.1002/eat.22681
Kessler RC, Andrews G, Mroczek D, Ustun B, Wittchen H-U (1998) The World Health Organization composite international diagnostic interview short-form (CIDI-SF). Int J Methods Psychiatr Res 7(4):171–185. https://doi.org/10.1002/mpr.47
doi: 10.1002/mpr.47
Kessler RC, Wittchen H-U, Abelson JM, Mcgonagle K, Schwarz N, Kendler KS, Zhao S (1998) Methodological studies of the composite international diagnostic interview (CIDI) in the US national comorbidity survey (NCS). Int J Methods Psychiatr Res 7(1):33–55. https://doi.org/10.1002/mpr.33
doi: 10.1002/mpr.33
Klibanski A, Biller BM, Schoenfeld DA, Herzog DB, Saxe VC (1995) The effects of estrogen administration on trabecular bone loss in young women with anorexia nervosa. The Journal of Clinical Endocrinology and Metabolism 80(3):898–904. https://doi.org/10.1210/jcem.80.3.7883849
pubmed: 7883849
doi: 10.1210/jcem.80.3.7883849
Konstantynowicz J, Kadziela-Olech H, Kaczmarski M, Zebaze RMD, Iuliano-Burns S, Piotrowska-Jastrzebska J, Seeman E (2005) Depression in anorexia nervosa: a risk factor for osteoporosis. J Clin Endocrinol Metab 90(9):5382–5385. https://doi.org/10.1210/jc.2005-0026
pubmed: 15941868
doi: 10.1210/jc.2005-0026
Legroux-Gerot I, Vignau J, d’Herbomez M, Flipo R-M, Cortet B (2012) Predictive factors of change in BMD at 1 and 2 years in women with anorexia nervosa: A study of 146 cases. Osteoporosis International : A Journal Established as Result of Cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA. https://doi.org/10.1007/s00198-012-1919-8
doi: 10.1007/s00198-012-1919-8
Lépine JP, Godchau M, Brun P, Lempérière T (1985) Evaluation of anxiety and depression among patients hospitalized on an internal medicine service. Ann Med Psychol 143(2):175–189
Lewiecki EM, Gordon CM, Baim S, Binkley N, Bilezikian JP, Kendler DL, Zemel BS (2008) Special report on the 2007 adult and pediatric position development conferences of the international society for clinical densitometry. Osteoporos Int A J Establ Result Cooper Between Eur Found Osteoporos Nat Osteoporos Found USA 19(10):1369–1378. https://doi.org/10.1007/s00198-008-0689-9
doi: 10.1007/s00198-008-0689-9
Mattar L, Huas C, Godart N, EVHAN group (2012) Relationship between affective symptoms and malnutrition severity in severe Anorexia Nervosa. PLoS ONE 7(11):e49380. https://doi.org/10.1371/journal.pone.0049380
pubmed: 23185320
pmcid: 3504017
doi: 10.1371/journal.pone.0049380
Misra M, Aggarwal A, Miller KK, Almazan C, Worley M, Soyka LA, Klibanski A (2004) Effects of anorexia nervosa on clinical, hematologic, biochemical, and bone density parameters in community-dwelling adolescent girls. Pediatrics 114(6):1574–1583. https://doi.org/10.1542/peds.2004-0540
pubmed: 15574617
doi: 10.1542/peds.2004-0540
Misra M, Le Clair M, Mendes N, Miller KK, Lawson E, Meenaghan E, Klibanski A (2010) Use of SSRIs may impact bone density in adolescent and young women with anorexia nervosa. CNS Spectr 15(9):579–586
pubmed: 24790401
pmcid: 4001118
doi: 10.1017/S1092852900000559
Misra M, Golden NH, Katzman DK. State of the art systematic review of bone disease in anorexia nervosa. Int J Misra, M., Golden, N. H., & Katzman, D. K (2016) State of the art systematic review of bone disease in anorexia nervosa. The International Journal of Eating Disorders 49(3):276–292. https://doi.org/10.1002/eat.22451
doi: 10.1002/eat.22451
Mollard E, Bilek L, Waltman N (2018) Emerging evidence on the link between depressive symptoms and bone loss in postmenopausal women. Int J Women Health 10:1–9. https://doi.org/10.2147/IJWH.S147006
doi: 10.2147/IJWH.S147006
Morgan HG, Hayward AE (1988) Clinical assessment of anorexia nervosa. The Morgan-Russell outcome assessment schedule. Br J Psychiatry J Mental Sci 152:367–371
doi: 10.1192/bjp.152.3.367
Ravaud P, Reny JL, Giraudeau B, Porcher R, Dougados M, Roux C (1999) Individual smallest detectable difference in bone mineral density measurements. J Bone Miner Res Off J Am Soc Bone Miner Res 14(8):1449–1456. https://doi.org/10.1359/jbmr.1999.14.8.1449
doi: 10.1359/jbmr.1999.14.8.1449
Robinson L, Aldridge V, Clark EM, Misra M, Micali N (2016) A systematic review and meta-analysis of the association between eating disorders and bone density. Osteoporos Int A J Establ Result Cooper Between Eur Found Osteoporos Nat Osteoporos Found USA 27(6):1953–1966. https://doi.org/10.1007/s00198-015-3468-4
doi: 10.1007/s00198-015-3468-4
Roux H, Blanchet C, Stheneur C, Chapelon E, Godart N (2013) Somatic outcome among patients hospitalised for anorexia nervosa in adolescence: disorders reported and links with global outcome. Eat Weight Disord EWD 18(2):175–182. https://doi.org/10.1007/s40519-013-0030-2
pubmed: 23760846
doi: 10.1007/s40519-013-0030-2
Roux, H., Ali, A., Lambert, S., Radon, L., Huas, C., Curt, F., EVHAN Group (2016) Predictive factors of dropout from inpatient treatment for anorexia nervosa. BMC Psychiatry 16(1):339. https://doi.org/10.1186/s12888-016-1010-7
doi: 10.1186/s12888-016-1010-7
Rytwinski NK, Fresco DM, Heimberg RG, Coles ME, Liebowitz MR, Cissell S, Hofmann SG (2009) Screening for social anxiety disorder with the self-report version of the Liebowitz Social Anxiety Scale. Depress Anxiety 26(1):34–38. https://doi.org/10.1002/da.20503
pubmed: 18781659
doi: 10.1002/da.20503
Schweiger JU, Schweiger U, Hüppe M, Kahl KG, Greggersen W, Fassbinder E (2016) Bone density and depressive disorder: A meta-analysis. Brain Behav. https://doi.org/10.1002/brb3.489
pubmed: 27547495
pmcid: 4980464
doi: 10.1002/brb3.489
Soyka LA, Grinspoon S, Levitsky LL, Herzog DB, Klibanski A (1999) The effects of anorexia nervosa on bone metabolism in female adolescents. J Clin Endocrinol Metab 84(12):4489–4496. https://doi.org/10.1210/jcem.84.12.6207
pubmed: 10599707
doi: 10.1210/jcem.84.12.6207
Soyka LA, Misra M, Frenchman A, Miller KK, Grinspoon S, Schoenfeld DA, Klibanski A (2002) Abnormal bone mineral accrual in adolescent girls with anorexia nervosa. J Clin Endocrinol Metab 87(9):4177–4185. https://doi.org/10.1210/jc.2001-011889
pubmed: 12213868
doi: 10.1210/jc.2001-011889
Winston AP, Alwazeer AEF, Bankart MJG (2008) Screening for osteoporosis in anorexia nervosa: Prevalence and predictors of reduced bone mineral density. Int J Eat Disord 41(3):284–287. https://doi.org/10.1002/eat.20501
pubmed: 18176948
doi: 10.1002/eat.20501
Yao SN, Note I, Fanget F, Albuisson E, Bouvard M, Jalenques I, Cottraux J (1999) Social anxiety in patients with social phobia: validation of the Liebowitz social anxiety scale: the French version. L’Encephale 25(5):429–435
pubmed: 10598306
Zigmond AS, Snaith RP (1983) The hospital anxiety and depression scale. Acta Psychiatr Scand 67(6):361–370
doi: 10.1111/j.1600-0447.1983.tb09716.x
Zipfel S, Seibel MJ, Löwe B, Beumont PJ, Kasperk C, Herzog W (2001) Osteoporosis in eating disorders: a follow-up study of patients with anorexia and bulimia nervosa. J Clin Endocrinol Metab 86(11):5227–5233. https://doi.org/10.1210/jcem.86.11.8050
pubmed: 11701682
doi: 10.1210/jcem.86.11.8050