TRPV4 channel blockade does not modulate skin vasodilation and sweating during hyperthermia or cutaneous postocclusive reactive and thermal hyperemia.
Adult
Female
Humans
Hyperemia
/ metabolism
Hyperthermia
/ metabolism
Leucine
/ administration & dosage
Male
Membrane Transport Modulators
/ administration & dosage
Microdialysis
Morpholines
/ administration & dosage
Piperidines
/ administration & dosage
Pyrroles
/ administration & dosage
Quinolines
/ administration & dosage
Regional Blood Flow
Skin
/ blood supply
Sulfonamides
/ administration & dosage
Sweating
TRPV Cation Channels
/ antagonists & inhibitors
Time Factors
Vasodilation
Young Adult
TRP
heat stroke
ion channel
microcirculation
perspiration
thermoregulation
Journal
American journal of physiology. Regulatory, integrative and comparative physiology
ISSN: 1522-1490
Titre abrégé: Am J Physiol Regul Integr Comp Physiol
Pays: United States
ID NLM: 100901230
Informations de publication
Date de publication:
01 04 2021
01 04 2021
Historique:
pubmed:
22
10
2020
medline:
11
5
2021
entrez:
21
10
2020
Statut:
ppublish
Résumé
Transient receptor potential vanilloid 4 (TRPV4) channels exist on vascular endothelial cells and eccrine sweat gland secretory cells in human skin. Here, we assessed whether TRPV4 channels contribute to cutaneous vasodilation and sweating during whole body passive heat stress (
Identifiants
pubmed: 33085914
doi: 10.1152/ajpregu.00123.2020
doi:
Substances chimiques
GSK2193874
0
HC-067047
0
Membrane Transport Modulators
0
Morpholines
0
N-(1-((4-(2-(((2,4-dichlorophenyl)sulfonyl)amino)-3-hydroxypropanoyl)-1-piperazinyl)carbonyl)-3-methylbutyl)-1-benzothiophene-2-carboxamide
0
Piperidines
0
Pyrroles
0
Quinolines
0
Sulfonamides
0
TRPV Cation Channels
0
TRPV4 protein, human
0
Leucine
GMW67QNF9C
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM