Association between Serum Zinc Levels and Clinical Index or the Body Composition in Incident Hemodialysis Patients.
hemodialysis
nutritional status
serum zinc levels
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Oct 2020
19 Oct 2020
Historique:
received:
12
09
2020
revised:
14
10
2020
accepted:
15
10
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
21
4
2021
Statut:
epublish
Résumé
The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear. This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders. Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant. Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.
Sections du résumé
BACKGROUND
BACKGROUND
The relationships between serum zinc levels and body composition or clinical outcomes of incident hemodialysis (HD) patients remain unclear.
METHODS
METHODS
This prospective observational study examined the relationships between serum zinc levels and clinical indexes, including body composition, in 142 incident HD patients using a bioelectrical impedance analysis. Patients were divided into three groups according to baseline serum zinc levels: tertile, <45, 45-59, and ≥60 µg/dL. The reference group was set as ≥60 µg/dL. Cox's regression analysis was performed to investigate the relationships between serum zinc categories and cardiovascular events and all-cause mortality after adjustments for potential confounders.
RESULTS
RESULTS
Serum zinc levels positively correlated with the nutritional index and negatively correlated with fluid volume markers. In a mean follow-up of 2.5 years, there were 20 cases of cardiovascular events and 15 of all-cause mortality. In the Cox's regression analysis for cardiovascular events and all-cause mortality, the hazard ratio increased with a decrease in serum zinc levels, but was not significant.
CONCLUSION
CONCLUSIONS
Serum zinc levels were associated with nutritional and fluid volume markers in incident HD patients. To clarify the relationship between serum zinc levels and cardiovascular events or mortality, further studies with a larger number of cases will be necessary.
Identifiants
pubmed: 33086501
pii: nu12103187
doi: 10.3390/nu12103187
pmc: PMC7603268
pii:
doi:
Substances chimiques
Biomarkers
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Références
J Ren Nutr. 2004 Jul;14(3):164-9
pubmed: 15232795
Nutrients. 2020 Feb 23;12(2):
pubmed: 32102170
Am J Clin Nutr. 1998 Aug;68(2 Suppl):442S-446S
pubmed: 9701159
JPEN J Parenter Enteral Nutr. 2016 Feb;40(2):159-211
pubmed: 26773077
J Ren Nutr. 2010 Sep;20(5):314-20
pubmed: 20303790
Clin Nutr. 2003 Aug;22(4):415-21
pubmed: 12880610
Int J Med Sci. 2019 Jun 7;16(7):939-948
pubmed: 31341407
Nutrients. 2017 Jun 17;9(6):
pubmed: 28629136
Nephrol Dial Transplant. 2020 Jul 1;35(7):1094-1098
pubmed: 32417896
Eur J Clin Nutr. 2007 Mar;61(3):375-81
pubmed: 16969379
Blood Purif. 2020;49(1-2):178-184
pubmed: 31851988
Nephrol Dial Transplant. 2020 Jul 1;35(7):1171-1178
pubmed: 31298287
Am J Clin Nutr. 2005 Oct;82(4):777-83
pubmed: 16210706
Acta Pharmacol Sin. 2018 Jul;39(7):1120-1132
pubmed: 29926844
Clin Nephrol. 1979 Jul;12(1):18-21
pubmed: 477052
Mol Nutr Food Res. 2012 Jan;56(1):77-87
pubmed: 22076675
Nutrition. 2019 Nov - Dec;67-68:110532
pubmed: 31445314
J Ren Nutr. 2012 Sep;22(5):490-8
pubmed: 22153383
Eur J Clin Nutr. 2014 Jun;68(6):683-9
pubmed: 24736681
J Nutr. 2005 Sep;135(9):2114-8
pubmed: 16140885
Int J Mol Sci. 2020 Apr 22;21(8):
pubmed: 32331308
J Am Coll Nutr. 2008 Oct;27(5):577-87
pubmed: 18845708
Biol Trace Elem Res. 2010 Jun;135(1-3):16-21
pubmed: 19760368
J Nephrol. 2017 Feb;30(1):109-118
pubmed: 27003153
Kidney Int Suppl. 1989 Nov;27:S269-73
pubmed: 2636669
Saudi J Kidney Dis Transpl. 2010 Jul;21(4):641-5
pubmed: 20587866
Nephrology (Carlton). 2011 May;16(4):389-95
pubmed: 21054667
Biomed Res Int. 2017;2017:1024769
pubmed: 29457023
Clin Nutr. 2016 Dec;35(6):1522-1529
pubmed: 27117682
Contrib Nephrol. 2007;155:18-28
pubmed: 17369710
Nutrients. 2020 Jan 19;12(1):
pubmed: 31963892
Nutrients. 2020 Feb 28;12(3):
pubmed: 32121224
Cell Death Dis. 2014 Jan 30;5:e1040
pubmed: 24481454
Ren Fail. 2013;35(5):680-5
pubmed: 23650973
Antioxidants (Basel). 2019 Jun 06;8(6):
pubmed: 31174269
Am J Nephrol. 1986;6(6):422-6
pubmed: 3565500
J Cachexia Sarcopenia Muscle. 2019 Jun;10(3):479-484
pubmed: 30977979
Int J Artif Organs. 1998 May;21(5):274-8
pubmed: 9684909
Int J Med Sci. 2013;10(1):79-89
pubmed: 23289009
Nutrients. 2018 Jul 27;10(8):
pubmed: 30060473
BMC Med. 2009 May 19;7:25
pubmed: 19454005
Nutr Res. 2019 Nov;71:8-20
pubmed: 31708186