Decreased Histone Acetylation Levels at Th1 and Regulatory Loci after Induction of Food Allergy.
Acetylation
Animals
B-Lymphocytes
/ immunology
Disease Models, Animal
Epigenomics
Female
Gene Expression
Histones
/ metabolism
Immunoglobulin E
/ blood
Mast Cells
/ immunology
Mice, Inbred C3H
Milk Hypersensitivity
/ genetics
STAT6 Transcription Factor
T-Lymphocytes, Regulatory
/ immunology
Th1 Cells
Th17 Cells
/ immunology
Whey
/ immunology
cow’s milk allergy
epigenetics
food allergy
histone acetylation
whey
Journal
Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595
Informations de publication
Date de publication:
19 Oct 2020
19 Oct 2020
Historique:
received:
25
09
2020
revised:
13
10
2020
accepted:
16
10
2020
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
21
4
2021
Statut:
epublish
Résumé
Immunoglobulin E (IgE)-mediated allergy against cow's milk protein fractions such as whey is one of the most common food-related allergic disorders of early childhood. Histone acetylation is an important epigenetic mechanism, shown to be involved in the pathogenesis of allergies. However, its role in food allergy remains unknown. IgE-mediated cow's milk allergy was successfully induced in a mouse model, as demonstrated by acute allergic symptoms, whey-specific IgE in serum, and the activation of mast cells upon a challenge with whey protein. The elicited allergic response coincided with reduced percentages of regulatory T (Treg) and T helper 17 (Th17) cells, matching decreased levels of H3 and/or H4 histone acetylation at pivotal Treg and Th17 loci, an epigenetic status favoring lower gene expression. In addition, histone acetylation levels at the crucial T helper 1 (Th1) loci were decreased, most probably preceding the expected reduction in Th1 cells after inducing an allergic response. No changes were observed for T helper 2 cells. However, increased histone acetylation levels, promoting gene expression, were observed at the signal transducer and activator of transcription 6 (
Identifiants
pubmed: 33086571
pii: nu12103193
doi: 10.3390/nu12103193
pmc: PMC7603208
pii:
doi:
Substances chimiques
Histones
0
STAT6 Transcription Factor
0
Stat6 protein, mouse
0
Immunoglobulin E
37341-29-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
L.M., D.H.V.-G., T.M.D.W., L.M.J.K., J.G., B.C.A.M.v.E., and M.M.T. are/were (partly) employed at Danone Nutricia Research. D.H.V.-G reports personal fees from Merck Sharp & Dohme outside of the submitted work. All other authors report no potential conflict of interest.
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