The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks.
Animals
Chromatin Assembly and Disassembly
Chromosomal Proteins, Non-Histone
/ metabolism
DNA
/ metabolism
DNA Breaks, Double-Stranded
DNA End-Joining Repair
DNA Helicases
/ metabolism
DNA-Binding Proteins
/ metabolism
Humans
Mammals
/ genetics
Nuclear Proteins
/ metabolism
Recombinational DNA Repair
Transcription Factors
/ metabolism
BAF
BRG1
Cancer
Chromatin remodeling
DNA repair
Double strand breaks
SMARCA4
SWI/SNF
Journal
DNA repair
ISSN: 1568-7856
Titre abrégé: DNA Repair (Amst)
Pays: Netherlands
ID NLM: 101139138
Informations de publication
Date de publication:
09 2020
09 2020
Historique:
entrez:
22
10
2020
pubmed:
23
10
2020
medline:
25
3
2021
Statut:
ppublish
Résumé
Mammalian cells possess multiple closely related SWI/SNF chromatin remodelling complexes. These complexes have been implicated in the cellular response to DNA double strand breaks (DSBs). Evidence suggests that SWI/SNF complexes contribute to successful repair via both the homologous recombination and non-homologous end joining pathways. In addition, repressing transcription near DSBs is dependent on SWI/SNF activity. Understanding these roles is important because SWI/SNF complexes are frequently dysregulated in cancer, and DNA DSB repair defects have the potential to be therapeutically exploited. In this graphical review, we summarise what is known about SWI/SNF contribution to DNA DSB responses in mammalian cells and provide an overview of the SWI/SNF-encoding gene alteration spectrum in human cancers.
Identifiants
pubmed: 33087260
pii: S1568-7864(20)30167-1
doi: 10.1016/j.dnarep.2020.102919
pii:
doi:
Substances chimiques
BANF1 protein, human
0
Chromosomal Proteins, Non-Histone
0
DNA-Binding Proteins
0
Nuclear Proteins
0
Transcription Factors
0
DNA
9007-49-2
SMARCA4 protein, human
EC 3.6.1.-
DNA Helicases
EC 3.6.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
102919Subventions
Organisme : Cancer Research UK
ID : C7905/A25715
Pays : United Kingdom
Informations de copyright
Copyright © 2020. Published by Elsevier B.V.