Laminar analysis of the cortical T1/T2-weighted ratio at 7T.

Adult Aged Cerebral Cortex / diagnostic imaging Female Humans Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis, Chronic Progressive / diagnostic imaging Multiple Sclerosis, Relapsing-Remitting / diagnostic imaging

Journal

Neurology(R) neuroimmunology & neuroinflammation
ISSN: 2332-7812
Titre abrégé: Neurol Neuroimmunol Neuroinflamm
Pays: United States
ID NLM: 101636388

Informations de publication

Date de publication:
11 2020
Historique:
received: 17 04 2020
accepted: 04 08 2020
entrez: 22 10 2020
pubmed: 23 10 2020
medline: 5 10 2021
Statut: epublish

Résumé

In this observational study, we explored cortical structure as function of cortical depth through a laminar analysis of the T1/T2-weighted (T1w/T2w) ratio, which has been related to dendrite density in ex vivo brain tissue specimens of patients with MS. In 39 patients (22 relapsing-remitting, 13 female, age 41.1 ± 10.6 years; 17 progressive, 11 female, age 54.1 ± 9.9 years) and 21 healthy controls (8 female, , age 41.6 ± 10.6 years), we performed a voxel-wise analysis of T1w/T2w ratio maps from high-resolution 7T images from the subpial surface to the gray matter/white matter boundary. Six layers were sampled to ensure accuracy based on mean cortical thickness and image resolution. At the voxel-wise comparison ( Laminar analysis of T1w/T2w ratio mapping confirms the presence of cortical damage in MS and shows a variable expression of intracortical damage according to the disease phenotype. Although in the relapsing-remitting stage, only the subpial layer appears susceptible to damage, in progressive patients, widespread cortical abnormalities can be observed, not only, as described before, with regard to myelin/iron concentration but, possibly, to other microstructural features.

Identifiants

DOI: 10.1212/NXI.0000000000000900 PMID: 33087580 PMC: PMC7641144
pubmed: 33087580
pii: 7/6/e900
doi: 10.1212/NXI.0000000000000900
pmc: PMC7641144
pii:
doi:

Types de publication

Journal Article Observational Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2020 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology.

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Auteurs

Maria Petracca (M)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.
ORCID: 0000-0001-9429-2769

Mohamed M El Mendili (MM)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.
ORCID: 0000-0002-4020-0926

Matteo Moro (M)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.

Sirio Cocozza (S)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.
ORCID: 0000-0002-0300-5160

Kornelius Podranski (K)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.
ORCID: 0000-0001-5789-6387

Lazar Fleysher (L)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy.

Matilde Inglese (M)

From the Department of Neurology (M.P., M.M.E.M., M.M., S.C., K.P., M.I.), Icahn School of Medicine at Mount Sinai, NY; Aix-Marseille Univ (M.M.E.M.), CNRS, CRMBM; APHM (M.M.E.M.), Hôpital de la Timone, CEMEREM, Marseille, France; Department of Informatics (M.M.), Bioengineering, Robotics and Systems Engineering (DIBRIS) and Machine Learning Genoa Center (MaLGa), University of Genoa; Department of Advanced Biomedical Sciences (S.C.), University of Naples "Federico II", Italy; Department of Radiology (L.F.), Icahn School of Medicine at Mount Sinai, NY; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics (M.I.), Maternal and Child Health (DINOGMI) and Center of Excellence for Biomedical Research, University of Genoa; and Ospedale Policlinico San Martino-IRCCS (M.I.), Genoa, Italy. matilde.inglese@mssm.edu.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Laminar analysis of the cortical...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Laminar analysis of the cortical...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Prosencéphale › Télencéphale › Cerveau › Cortex cérébral › Laminar analysis of the cortical...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Laminar analysis of the cortical...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Laminar analysis of the cortical...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Laminar analysis of the cortical...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Sclérose en plaques chronique progressive › Laminar analysis of the cortical...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Maladies auto-immunes du système nerveux › Maladies démyélinisantes auto-immunes du SNC › Sclérose en plaques › Sclérose en plaques récurrente-rémittente › Laminar analysis of the cortical...