Role of B Cells in Multiple Sclerosis and Related Disorders.
Journal
Annals of neurology
ISSN: 1531-8249
Titre abrégé: Ann Neurol
Pays: United States
ID NLM: 7707449
Informations de publication
Date de publication:
01 2021
01 2021
Historique:
received:
03
07
2020
revised:
05
10
2020
accepted:
05
10
2020
pubmed:
23
10
2020
medline:
3
2
2021
entrez:
22
10
2020
Statut:
ppublish
Résumé
The success of clinical trials of selective B-cell depletion in patients with relapsing multiple sclerosis (MS) and primary progressive MS has led to a conceptual shift in the understanding of MS pathogenesis, away from the classical model in which T cells were the sole central actors and toward a more complex paradigm with B cells having an essential role in both the inflammatory and neurodegenerative components of the disease process. The role of B cells in MS was selected as the topic of the 27th Annual Meeting of the European Charcot Foundation. Results of the meeting are presented in this concise review, which recaps current concepts underlying the biology and therapeutic rationale behind B-cell-directed therapeutics in MS, and proposes strategies to optimize the use of existing anti-B-cell treatments and provide future directions for research in this area. ANN NEUROL 2021;89:13-23.
Identifiants
pubmed: 33091175
doi: 10.1002/ana.25927
pmc: PMC8007167
mid: NIHMS1679531
doi:
Substances chimiques
Autoantibodies
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
13-23Subventions
Organisme : NINDS NIH HHS
ID : R35 NS111644
Pays : United States
Informations de copyright
© 2020 American Neurological Association.
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