Effects of topical application of tramadol with/without dexmedetomidine and proparacaine on corneal sensitivity in rats.
Corneal anesthesia
Dexmedetomidine hydrochloride
Esthesiometry
Proparacaine hydrochloride
Rat
Tramadol hydrochloride
Journal
International ophthalmology
ISSN: 1573-2630
Titre abrégé: Int Ophthalmol
Pays: Netherlands
ID NLM: 7904294
Informations de publication
Date de publication:
Feb 2021
Feb 2021
Historique:
received:
15
05
2020
accepted:
01
10
2020
pubmed:
24
10
2020
medline:
22
6
2021
entrez:
23
10
2020
Statut:
ppublish
Résumé
To evaluate the corneal anesthetic effect following topical application of tramadol alone and in combination with dexmedetomidine, and compare it to proparacaine, in clinically healthy rats. A randomized, crossover study was performed. Twenty Wistar albino rats (n = 40 eyes) were used. Corneal touch threshold (CTT) measurements (in mm) were obtained using a Cochet-Bonnet aesthesiometer. CTT measurements were obtained at baseline, 1-min following application of the topical anesthetic agent, and repeated at 5-min intervals up to 75 min. The topical protocol involved 3 treatment conditions, separated by a 2-week washout period: proparacaine, tramadol alone, and tramadol in combination with dexmedetomidine. CTT values were significantly decreased compared to baseline at each timepoint until completion of the 75-min evaluation in all treated eyes, regardless of the assigned treatment (p < 0.0083). With tramadol, complete corneal anesthesia (CTT = 0) was achieved within 1-5 min in 18 eyes and ranged from 5 to 25 min. Co-administration of dexmedetomidine to tramadol resulted in significantly increased CTT values from 5 to 20 min following topical application, compared to tramadol alone (p < 0.0083), and complete corneal anesthesia was achieved in only 14 out of 20 treated eyes. Tramadol might be a useful alternative to topical anesthetic agents, providing a dose-related corneal anesthetic effect. Co-administration of dexmedetomidine does not potentiate its anesthetic effect. The underlying mechanism(s) of drug antagonism between tramadol and dexmedetomidine remains to be determined.
Identifiants
pubmed: 33095346
doi: 10.1007/s10792-020-01596-x
pii: 10.1007/s10792-020-01596-x
doi:
Substances chimiques
Anesthetics, Local
0
Dexmedetomidine
67VB76HONO
Ophthalmic Solutions
0
Propoxycaine
EPD1EH7F53
proxymetacaine
B4OB0JHI1X
Tramadol
39J1LGJ30J
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
465-473Références
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