Newly Synthesized Imino-Derivatives Analogues of Resveratrol Exert Inhibitory Effects in Breast Tumor Cells.
Antineoplastic Agents
/ chemical synthesis
Biological Availability
Breast Neoplasms
/ drug therapy
Cell Line, Tumor
Cell Proliferation
/ drug effects
DNA Topoisomerases, Type I
/ chemistry
DNA Topoisomerases, Type II
/ chemistry
Female
HEK293 Cells
Humans
Imines
/ chemistry
Molecular Docking Simulation
Poly-ADP-Ribose Binding Proteins
/ antagonists & inhibitors
Resveratrol
/ analogs & derivatives
Topoisomerase I Inhibitors
/ chemistry
antitumor activity
apoptosis
bioavailability
breast cancer
resveratrol
resveratrol analogues
topoisomerases
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
21 Oct 2020
21 Oct 2020
Historique:
received:
17
09
2020
revised:
16
10
2020
accepted:
20
10
2020
entrez:
24
10
2020
pubmed:
25
10
2020
medline:
17
4
2021
Statut:
epublish
Résumé
Breast cancer represents the most frequently diagnosed malignancy in women worldwide. Various therapeutics are currently used in order to halt the progression of breast tumor, even though certain side effects may limit the beneficial effects. In recent years, many efforts have been addressed to the usefulness of natural compounds as anticancer agents due to their low toxicity. Resveratrol, a stilbene found in grapes, berries, peanuts and soybeans, has raised a notable interest for its antioxidant, anti-inflammatory, and antitumor properties. Here, we report the design, the synthesis and the characterization of the anticancer activity of a small series of imino
Identifiants
pubmed: 33096835
pii: ijms21207797
doi: 10.3390/ijms21207797
pmc: PMC7589783
pii:
doi:
Substances chimiques
Antineoplastic Agents
0
Imines
0
Poly-ADP-Ribose Binding Proteins
0
Topoisomerase I Inhibitors
0
DNA Topoisomerases, Type I
EC 5.99.1.2
TOP1 protein, human
EC 5.99.1.2
DNA Topoisomerases, Type II
EC 5.99.1.3
TOP2A protein, human
EC 5.99.1.3
Resveratrol
Q369O8926L
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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