Breast cancer in the oldest old (≥ 89 years): Tumor characteristics, treatment choices, clinical outcomes and literature review.

Aged, 80 and over Breast Neoplasms / diagnosis Breast Neoplasms, Male / diagnosis Carcinoma in Situ / diagnosis Carcinoma, Ductal, Breast / diagnosis Carcinoma, Lobular / diagnosis Chemotherapy, Adjuvant Clinical Decision-Making Disease Progression Female Follow-Up Studies Humans Male Mastectomy Neoplasm Grading Neoplasm Invasiveness Neoplasm Metastasis Neoplasm Recurrence, Local / pathology Neoplasm Staging Radiotherapy, Adjuvant Receptor, ErbB-2 / metabolism Receptors, Estrogen / metabolism Receptors, Progesterone / metabolism Retrospective Studies Survival Rate Triple Negative Breast Neoplasms / diagnosis
Age group Breast cancer Breast cancer treatment Elderly patients Oldest old Overtreatment Subpopulation Undertreatment

Journal

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
ISSN: 1532-2157
Titre abrégé: Eur J Surg Oncol
Pays: England
ID NLM: 8504356

Informations de publication

Date de publication:
04 2021
Historique:
received: 24 07 2020
revised: 04 10 2020
accepted: 07 10 2020
pubmed: 25 10 2020
medline: 28 9 2021
entrez: 24 10 2020
Statut: ppublish

Résumé

Risk of breast cancer increases with age and very few data are available in patients older than 89. A retrospective analysis on patients aged 89 and older treated between 2008 and 2019 at our certified breast center. The aim was to analyze clinical characteristics, decision-making, treatment, outcomes and open questions regarding this subpopulation for which there is a lack of guidelines. 58 patients included. Tumor characteristics were analyzed, 85% patients underwent surgery of which 44% had a mastectomy. The median follow-up and overall survival were 20 and 76 months, respectively.The median survival of metastatic and non-metastatic patients were 14 and 50 months, respectively. Most patients did not receive any adjuvant treatment and among these 14% had a relapse. Elderly patients should not be under or over-treated because of their age; they represent a large heterogeneous group deserving a sub-stratification for a better tailored treatment.

Identifiants

DOI: 10.1016/j.ejso.2020.10.008 PMID: 33097334
pubmed: 33097334
pii: S0748-7983(20)30840-4
doi: 10.1016/j.ejso.2020.10.008
pii:
doi:

Substances chimiques

Receptors, Estrogen 0
Receptors, Progesterone 0
ERBB2 protein, human EC 2.7.10.1
Receptor, ErbB-2 EC 2.7.10.1

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

796-803

Informations de copyright

Copyright © 2020 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of competing interest The authors declare that they have no conflict of interest.

Auteurs

Simona Di Lascio (S)

Oncology Institute of Southern Switzerland - IOSI, Bellinzona, Switzerland; CSSI, Centro di Senologia Della Svizzera Italiana, Ente Ospedaliero Cantonale - EOC, Switzerland. Electronic address: simona.dilascio@eoc.ch.

Enrico Tognazzo (E)

Gynecology and Obstetric Department, Ente Ospedaliero Cantonale - EOC, Lugano, Switzerland. Electronic address: enrico.tognazzo@hcuge.ch.

Sara Bigiotti (S)

Gynecology and Obstetric Department, Ente Ospedaliero Cantonale - EOC, Lugano, Switzerland.

Marta Bonollo (M)

Gynecology and Obstetric Department, Ente Ospedaliero Cantonale - EOC, Lugano, Switzerland.

Alberto Costa (A)

CSSI, Centro di Senologia Della Svizzera Italiana, Ente Ospedaliero Cantonale - EOC, Switzerland; European School of Oncology - ESO, Milano, Italy.

Olivia Pagani (O)

European School of Oncology - ESO, Milano, Italy; Interdisciplinary Cancer Service, Hopital Riviera-Chablais, Rennaz, Vaud, Geneva University Hospitals, Switzerland.

Francesco Meani (F)

CSSI, Centro di Senologia Della Svizzera Italiana, Ente Ospedaliero Cantonale - EOC, Switzerland; Gynecology and Obstetric Department, Ente Ospedaliero Cantonale - EOC, Lugano, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Sujet âgé de 80 ans ou plus › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeur du sein de l'homme › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Tumeurs › Tumeurs par type histologique › Tumeurs épithéliales épidermoïdes et glandulaires › Carcinomes › Épithélioma in situ › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Carcinome canalaire du sein › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Carcinome lobulaire › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Thérapeutique › Traitement médicamenteux › Traitement médicamenteux adjuvant › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Diagnostic › Prise de décision clinique › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études de suivi › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Procédures de chirurgie opératoire › Mastectomie › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Diagnostic › Pronostic › Grading des tumeurs › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Invasion tumorale › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Métastase tumorale › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Processus néoplasiques › Récidive tumorale locale › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Diagnostic › Pronostic › Stadification tumorale › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Thérapeutique › Radiothérapie › Radiothérapie adjuvante › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Marqueurs biologiques tumoraux › Récepteur ErbB-2 › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs aux stéroïdes › Récepteurs des oestrogènes › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs à la progestérone › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Mortalité › Taux de survie › Breast cancer in the oldest old (≥ 89 years):...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Maladies du sein › Tumeurs du sein › Tumeurs du sein triple-négatives › Breast cancer in the oldest old (≥ 89 years):...