Contact allergy to polyhexamethylene biguanide (polyaminopropyl biguanide).
allergic contact dermatitis
cosmetics
patch test
polyaminopropyl biguanide
polyhexamethylene biguanide
preservative
prevalence
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
May 2021
May 2021
Historique:
revised:
15
10
2020
received:
14
09
2020
accepted:
19
10
2020
pubmed:
25
10
2020
medline:
4
11
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
Polyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad-spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed, we have included PHMB as a screening allergen since 2016. To report the prevalence of positive patch test reactions to PHMB as a screening allergen in patients with suspected allergic contact dermatitis. A retrospective analysis of 1760 patch tested patients from July 2016 to December 2018 was performed. Polyaminopropyl biguanide 2.0% aqua was included in the extended Malmö baseline series during the study period. Of all patients, 1204 (68.4%) were female. Positive patch test reactions were reported in 19 patients (1.1%). The most common sites of lesions were face, head, and neck (52.6%). There was a significant correlation between concomitant reactions to PHMB and other cosmetic-related allergens. The prevalence of positive reactions to PHMB was higher than that previously reported. Patch testing with PHMB should be performed in patients with dermatitis who have lesions on the face, head, and neck.
Sections du résumé
BACKGROUND
BACKGROUND
Polyaminopropyl biguanide (INCI name) and polyhexamethylene biguanide (PHMB) are polymeric biguanides. PHMB is a broad-spectrum antimicrobial substance used as a preservative in many products. Due to our limited knowledge on PHMB contact allergy frequency and the fact that cases of allergic contact dermatitis to PHMB might be missed, we have included PHMB as a screening allergen since 2016.
OBJECTIVE
OBJECTIVE
To report the prevalence of positive patch test reactions to PHMB as a screening allergen in patients with suspected allergic contact dermatitis.
METHODS
METHODS
A retrospective analysis of 1760 patch tested patients from July 2016 to December 2018 was performed. Polyaminopropyl biguanide 2.0% aqua was included in the extended Malmö baseline series during the study period.
RESULTS
RESULTS
Of all patients, 1204 (68.4%) were female. Positive patch test reactions were reported in 19 patients (1.1%). The most common sites of lesions were face, head, and neck (52.6%). There was a significant correlation between concomitant reactions to PHMB and other cosmetic-related allergens.
CONCLUSION
CONCLUSIONS
The prevalence of positive reactions to PHMB was higher than that previously reported. Patch testing with PHMB should be performed in patients with dermatitis who have lesions on the face, head, and neck.
Identifiants
pubmed: 33098110
doi: 10.1111/cod.13728
pmc: PMC8048451
doi:
Substances chimiques
Biguanides
0
Cosmetics
0
Preservatives, Pharmaceutical
0
polyaminopropylbiguanide
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
326-331Informations de copyright
© 2020 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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