Predicting Factors for Oncological and Functional Outcome in Hypopharyngeal Cancer.
Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
/ therapeutic use
Chemoradiotherapy
/ statistics & numerical data
Disease-Free Survival
Female
Follow-Up Studies
Humans
Hypopharyngeal Neoplasms
/ diagnosis
Hypopharynx
/ pathology
Incidence
Laryngectomy
/ statistics & numerical data
Lymphatic Metastasis
Male
Middle Aged
Neoplasm Recurrence, Local
/ epidemiology
Organ Sparing Treatments
/ methods
Prognosis
Retrospective Studies
Risk Assessment
/ statistics & numerical data
Risk Factors
Salvage Therapy
/ methods
Squamous Cell Carcinoma of Head and Neck
/ diagnosis
Survival Rate
Hypopharyngeal cancer
feeding tube
functional outcome
oncologic outcome
quality of life
relapse
tracheostomy
Journal
The Laryngoscope
ISSN: 1531-4995
Titre abrégé: Laryngoscope
Pays: United States
ID NLM: 8607378
Informations de publication
Date de publication:
05 2021
05 2021
Historique:
revised:
31
08
2020
received:
01
07
2020
accepted:
05
10
2020
pubmed:
25
10
2020
medline:
8
5
2021
entrez:
24
10
2020
Statut:
ppublish
Résumé
Hypopharyngeal squamous cell carcinoma (SCC) is a rare but aggressive malignancy, with low survival rates and high incidence of tumor and treatment-related morbidity. This study aims to analyze the long-term oncologic and functional outcomes of a large cohort of patients and to determine prognostic factors. Retrospective cohort study. The records of all patients diagnosed with hypopharyngeal SCC and treated with curative intent at our tertiary referral center were reviewed. Patient and initial disease characteristics, features, and complications of primary treatment, recurrence patterns, and corresponding treatments and the oncologic and functional long-term outcome were determined. For a total of 179 patients, primary radiotherapy (RT) was the predominant treatment modality (78%), whereas 22% underwent primary surgery. The median, 2-year, and 5-year overall survival (OS) for the study cohort were 47 months, 64% and 43%. The median survival after first and second relapse was 7 and 6 months, respectively. The 2 and 5-year relapse-free survival (RFS) was 52% and 36%. The median RFS after first relapse and salvage treatment was 9 months. A nodal status of ≥cN2 (HR = 1.89, CI:1.21-3.05, P < .005) and any other primary tumor localization than pyriform sinus (HR = 1.60, CI: 1.04-2.42, P < .05) were identified as independent risk factors for shorter OS and RFS. Regarding functional outcome, the 2- and 5-year laryngectomy-free-survival was 55% and 37%, respectively. In this large cohort with long-term follow-up, any other primary tumor localization than pyriform sinus and a nodal status of ≥cN2 were identified as risk factors for reduced OS and RFS. 4 Laryngoscope, 131:E1543-E1549, 2021.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
E1543-E1549Informations de copyright
© 2020 American Laryngological, Rhinological and Otological Society Inc, "The Triological Society" and American Laryngological Association (ALA).
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