A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.

Animals B-Lymphocytes / immunology Chromatin / genetics Computational Biology / methods Cytidine Deaminase / genetics Disease Models, Animal Disease Susceptibility Enzyme Activation Fluorescent Antibody Technique G-Quadruplexes Gene Expression Profiling Genome-Wide Association Study Germinal Center / immunology HLA Antigens / genetics Humans Hyper-IgM Immunodeficiency Syndrome / diagnosis Immunoglobulin Class Switching / genetics Immunophenotyping Lymphocyte Activation / genetics Lymphoma, Large B-Cell, Diffuse / etiology Mice Mice, Transgenic Mutation
AID CSR DLBCL G-quadruplex G4 HIGM MHC class II MHCII SHM activation-induced cytidine deaminase class switch recombination diffuse large B cell lymphoma germinal center B cells hyper-IgM syndrome somatic hypermutation

Journal

Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918

Informations de publication

Date de publication:
17 11 2020
Historique:
received: 16 03 2020
revised: 27 07 2020
accepted: 06 10 2020
pubmed: 26 10 2020
medline: 1 5 2021
entrez: 25 10 2020
Statut: ppublish

Résumé

Precise targeting of activation-induced cytidine deaminase (AID) to immunoglobulin (Ig) loci promotes antibody class switch recombination (CSR) and somatic hypermutation (SHM), whereas AID targeting of non-Ig loci can generate oncogenic DNA lesions. Here, we examined the contribution of G-quadruplex (G4) nucleic acid structures to AID targeting in vivo. Mice bearing a mutation in Aicda (AID

Identifiants

DOI: 10.1016/j.immuni.2020.10.003 PMID: 33098766 PMC: PMC8356774
pubmed: 33098766
pii: S1074-7613(20)30444-1
doi: 10.1016/j.immuni.2020.10.003
pmc: PMC8356774
mid: NIHMS1640946
pii:
doi:

Substances chimiques

Chromatin 0
HLA Antigens 0
Cytidine Deaminase EC 3.5.4.5

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

952-970.e11

Subventions

Organisme : NCI NIH HHS
ID : U54 CA137788
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI100874
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI072194
Pays : United States
Organisme : NCI NIH HHS
ID : T32 CA009149
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI124186
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA008748
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA132378
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI130043
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI072194
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests The authors declare no competing interests.

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Auteurs

William T Yewdell (WT)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Youngjun Kim (Y)

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Priyanka Chowdhury (P)

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Colleen M Lau (CM)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Ryan M Smolkin (RM)

Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA.

Kalina T Belcheva (KT)

Biochemistry, Cellular and Molecular Biology Allied Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Keith C Fernandez (KC)

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Montserrat Cols (M)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Wei-Feng Yen (WF)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Bharat Vaidyanathan (B)

Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA.

Davide Angeletti (D)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Adrian B McDermott (AB)

Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Jonathan W Yewdell (JW)

Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Joseph C Sun (JC)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA.

Jayanta Chaudhuri (J)

Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Immunology and Microbial Pathogenesis Program, Weill Cornell Graduate School of Medical Sciences, New York, NY 10065, USA; Gerstner Sloan Kettering Graduate School of Biomedical Sciences, New York, NY 10065, USA. Electronic address: chaudhuj@mskcc.org.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes B › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Sciences de l'information › Informatique › Biologie informatique › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Aminohydrolases › Nucleoside deaminases › Cytidine deaminase › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Prédisposition aux maladies › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Métabolisme › Activation enzymatique › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Technique d'immunofluorescence › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Conformation d'acide nucléique › G-quadruplexes › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de profil d'expression de gènes › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Système lymphatique › Tissu lymphoïde › Noeuds lymphatiques › Centre germinatif › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Isoantigènes › Antigènes d'histocompatibilité › Antigènes HLA › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Maladies du système immunitaire › Déficits immunitaires › Maladies d'immunodéficience primaire › Syndrome d'hyper-IgM › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes du système immunitaire › Phénomènes immunogénétiques › Réarrangement des gènes des lymphocytes B › Réarrangement des gènes des chaines lourdes des lymphocytes B › Commutation de classe des immunoglobulines › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Tests immunologiques › Immunophénotypage › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des lymphocytes › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › A Hyper-IgM Syndrome Mutation in...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › A Hyper-IgM Syndrome Mutation in...