A FRET-Based Fluorescent Probe to Screen Anticancer Drugs, Inhibiting p73 Binding to MDM2.


Journal

Chembiochem : a European journal of chemical biology
ISSN: 1439-7633
Titre abrégé: Chembiochem
Pays: Germany
ID NLM: 100937360

Informations de publication

Date de publication:
02 03 2021
Historique:
received: 21 09 2020
revised: 22 10 2020
pubmed: 27 10 2020
medline: 28 9 2021
entrez: 26 10 2020
Statut: ppublish

Résumé

The protein p73 acts as a transcription factor, resulting in tumour suppression. MDM2, an oncogenic protein, can negatively influence p73-mediated apoptosis by binding to p73 transactivation domains (TAD). Inhibition of the protein-protein interaction between p73 and oncogenic proteins is an attractive strategy for promoting p73-mediated apoptosis. Herein, we describe the use of a modified p73-TAD peptide for the FRET-based assay of the binding of p73-TAD to MDM2. The FRET probe, equipped with 1-naphthylamine (λ

Identifiants

pubmed: 33103305
doi: 10.1002/cbic.202000660
doi:

Substances chimiques

Antineoplastic Agents 0
Fluorescent Dyes 0
TP73 protein, human 0
Tumor Protein p73 0
MDM2 protein, human EC 2.3.2.27
Proto-Oncogene Proteins c-mdm2 EC 2.3.2.27

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

830-833

Subventions

Organisme : National Research Foundation
ID : NRF-2012 M3 A9 C4048775
Organisme : National Research Foundation
ID : NRF-2017 M3 A9 C8031995

Informations de copyright

© 2020 Wiley-VCH GmbH.

Références

 
W. G. Kaelin Jr, Oncogene 1999, 18, 7701;
E. C. Pietsch, S. M. Sykes, S. B. McMahon, M. E. Murphy, Oncogene 2008, 27, 6507-6521.
J.-C. Bourdon, Curr. Pharm. Biotechnol. 2007, 8, 332-336.
F. Mantovani, L. Collavin, G. Del Sal, Cell Death Differ. 2019, 26, 199-212.
M. Levrero, V. De Laurenzi, A. Costanzo, J. Gong, J. Wang, G. Melino, J. Cell Sci. 2000, 113, 1661-1670.
M.-K. Yoon, J.-H. Ha, M.-S. Lee, S.-W. Chi, BMB Rep. 2015, 48, 81-90.
A. I. Zaika, S. Kovalev, N. D. Marchenko, U. M. Moll, Cancer Res. 1999, 59, 3257-3263.
A. Bisso, L. Collavin, G. Del Sal, Curr. Pharm. Des. 2011, 17, 578-590.
 
Y. Haupt, R. Maya, A. Kazaz, M. Oren, Nature 1997, 387, 296-299;
M. H. G. Kubbutat, S. N. Jones, K. H. Vousden, Nature 1997, 387, 299-303.
 
M. Dobbelstein, S. Wienzek, C. König, J. Roth, Oncogene 1999, 18, 2101-2106;
X. Zeng, L. Chen, C. A. Jost, R. Maya, D. Keller, X. Wang, W. G. Kaelin, Jr., M. Oren, J. Chen, H. Lu, Mol. Cell. Biol. 1999, 19, 3257-3266.
 
M. Hosoda, T. Ozaki, K. Miyazaki, S. Hayashi, K. Furuya, K.-i. Watanabe, T. Nakagawa, T. Hanamoto, S. Todo, A. Nakagawara, Oncogene 2005, 24, 7156-7169;
A. M. Weissman, Mol. Cell. Biol. 2001, 2, 169-178.
I. R. Watson, A. Blanch, D. C. C. Lin, M. Ohh, M. S. Irwin, J. Biol. Chem. 2006, 281, 34096-34103.
 
M.-K. Yoon, B.-Y. Kim, J.-Y. Lee, J.-H. Ha, S. A. Kim, D.-H. Lee, M.-S. Lee, M.-K. Lee, J. S. Choi, J. H. Cho, J.-H. Kim, S. Kim, J. Song, S. G. Park, B. C. Park, K.-H. Bae, S. U. Choi, S.-W. Chi, J. Biol. Chem. 2018, 293, 19546-19558;
E. M. Phizicky, S. Fields, Microbiol. Rev. 1995, 59, 94-123.
 
Z. Ning, B. Hawley, C.-K. Chiang, D. Seebun, D. Figeys in Transcription Factor Regulatory Networks, Springer, 2014, pp. 1-13;
A. Yasgar, A. Jadhav, A. Simeonov, N. P. Coussens in High-Throughput Screening, Springer, 2016, pp. 77-98.
 
M. G. Ricardo, A. M. Ali, J. Plewka, E. Surmiak, B. Labuzek, C. G. Neochoritis, J. Atmaj, L. Skalniak, R. Zhang, T. A. Holak, M. Groves, D. G. Rivera, A. Domling, Angew Chem Int Ed Engl 2020, 59, 5235-5241;
P. Sang, Y. Shi, J. Lu, L. Chen, L. Yang, W. Borcherds, S. Abdulkadir, Q. Li, G. Daughdrill, J. Chen, J. Cai, J. Med Chem. 2020, 63, 975-986;
R. Zhang, T. Mayhood, P. Lipari, Y. Wang, J. Durkin, R. Syto, J. Gesell, C. McNemar, W. Windsor, Anal. Biochem. 2004, 331, 138-146.
A. Sznarkowska, K. Maleńczyk, L. Kadziński, K. P. Bielawski, B. Banecki, J. Zawacka-Pankau, FEBS Lett. 2011, 585, 255-260.
J. A. Broussard, B. Rappaz, D. J. Webb, C. M. Brown, Nat. Protoc. 2013, 8, 265-281.
 
W. R. Algar, N. Hildebrandt, S. S. Vogel, I. L. Medintz, Nat. Methods 2019, 16, 815-829;
J. R. Lakowicz, Principles of Fluorescence Spectroscopy, Springer, 2013.
 
J. H. Kim, J. Sumranjit, H. J. Kang, S. J. Chung, Mol. BioSyst. 2014, 10, 30-33;
H. J. Kang, J. H. Kim, S. J. Chung, Biosensors Bioelectronics 2015, 67, 413-418;
T. Durgannavar, S. J. Kwon, A. B. T. Ghisaidoobe, K. Rho, J. H. Kim, S.-Y. Yoon, H. J. Kang, S. J. Chung, ChemBioChem 2018, 19, 2495-2501;
H. J. Lee, Y. G. Lee, J. Kang, S. H. Yang, J. H. Kim, A. B. T. Ghisaidoobe, H. J. Kang, S.-R. Lee, M. H. Lim, S. J. Chung, Chem. Sci. 2019, 10, 1000-1007.
J.-S. Shin, J.-H. Ha, D.-H. Lee, K.-S. Ryu, K.-H. Bae, B. C. Park, S. G. Park, G.-S. Yi, S.-W. Chi, Cell Cycle 2015, 14, 533-543.
A. B. Ghisaidoobe, S. J. Chung, Int. J. Mol. Sci. 2014, 15, 22518-22538.
M. Katragadda, P. Magotti, G. Sfyroera, J. D. Lambris, J. Med. Chem. 2006, 49, 4616-4622.
K.-i. Setsukinai, Y. Urano, K. Kikuchi, T. Higuchi, T. Nagano, J. Chem. Soc. Perkin Trans. 2 2000, 2453-2457.
L. Gu, N. Zhu, H. W. Findley, M. Zhou, Leukemia 2008, 22, 730-739.

Auteurs

A Ro Han (AR)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419 (Republic of, Korea.

Trishaladevi Durgannavar (T)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419 (Republic of, Korea.

Dohee Ahn (D)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419 (Republic of, Korea.

Sang J Chung (SJ)

School of Pharmacy, Sungkyunkwan University, Suwon, 16419 (Republic of, Korea.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH