Adrenergic Modulation With Photochromic Ligands.
adrenergic receptors
azo compounds
neurotransmitters
photochromism
photopharmacology
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
15 02 2021
15 02 2021
Historique:
received:
01
08
2020
revised:
21
09
2020
pubmed:
27
10
2020
medline:
23
3
2021
entrez:
26
10
2020
Statut:
ppublish
Résumé
Adrenoceptors are ubiquitous and mediate important autonomic functions as well as modulating arousal, cognition, and pain on a central level. Understanding these physiological processes and their underlying neural circuits requires manipulating adrenergic neurotransmission with high spatio-temporal precision. Here we present a first generation of photochromic ligands (adrenoswitches) obtained via azologization of a class of cyclic amidines related to the known ligand clonidine. Their pharmacology, photochromism, bioavailability, and lack of toxicity allow for broad biological applications, as demonstrated by controlling locomotion in zebrafish and pupillary responses in mice.
Identifiants
pubmed: 33103317
doi: 10.1002/anie.202010553
doi:
Substances chimiques
Adrenergic Agents
0
Chromogenic Compounds
0
Ligands
0
Receptors, Adrenergic
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3625-3631Informations de copyright
© 2020 Wiley-VCH GmbH.
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